Archive Monthly Archives: September 2018

Cenegenics alternatives are often in the form of a low-T center, A low-T center focuses on low testosterone but does not focus on the causation of low-T symptoms

Traditional Low-T Centers May Be Causing You To Miss Out On Weight Loss

Article at a Glance

  • A low-T center focuses on low testosterone and bringing it within normal range. Sufficient monitoring is necessary to minimize side effects and risk, which is often lacking in most low-t centers.
  • Cenegenics all-encompassing approach is superior to a low-T clinic. Age management physicians focus on treating the hormone imbalance and the symptoms, but also investigate the root cause of the imbalance.
  • Cenegenics focuses on boosting energy, losing weight, enhancing libido, improving mental acuity, and achieving better sleep.

A Google search for “Cenegenics alternatives” yields roughly 35,600 results, and it is no surprise why. The world of age management medicine has exploded since the inception of our physician-founded program in 1997. From Ehormones to HealthGAINS, Andrologix to Royal Medical Centers, many hormone therapy services have emerged in response to the growing number of adults seeking out solutions for low hormone levels. Yet, as more and more individuals continue to prioritize their health through their middle ages and beyond, many continue to ask: How do Cenegenics alternatives compare to the original age management program?

As with many trailblazers, Cenegenics is superior in a number of ways. We are considered the “Gold Standard” in the industry, and beyond offering the best services for hormone treatment , our program extends far beyond hormone replacement therapy (HRT) and age management alone. If you are exploring your options for achieving optimal health and are wondering whether you might be able to attain the same results from a Cenegenics alternative, take the time to read through the following guide. From our comprehensive age management solutions that address all facets of adult wellness to our team of industry-leading specialists, we have cultivated a program for which, simply put, there is no viable alternative.

Going Beyond the Scope of a Low-T Center: Cenegenics Age Management

While there are indeed plenty of low-testosterone clinics to choose from, none compares to the robust age management solutions available through Cenegenics. Yet, many patients considering an alternative to Cenegenics might wonder whether such a comprehensive age management program is necessary. After all, if many of the issues associated with aging can be traced to hormonal changes, isn’t HRT enough? Not quite.

It is important to note that while hormone regulation is a critical element in a robust wellness program, for many adults, it is only one piece of the puzzle. Changing hormones can produce widespread effects, from impacting sleep duration and quality to posing ongoing weight challenges. Thus, while treating hormone imbalances themselves is a logical starting point for patients suffering from estrogen and testosterone deficiencies, a better approach is to treat not only the imbalance itself, but also the many frustrating symptoms it may produce, in concurrence.

physicians at a low-T center only focus on your testosterone levels, Cenegenics physicians focus on the root cause of your low testosterone, Cenegenics alternatives cannot compare to the all-encompassing Cenegenics Elite Health program

The Cenegenics difference lies in our commitment to helping you overcome all of the challenges associated with aging. We address health in the areas of sleep, cognition, weight management, libido, and energy levels, providing well-rounded yet individualized treatment to achieve real results. Our team excels in enhancing health across these five pillars through evidence-based, physician-developed strategies. Moreover, our approach is proactive: instead of waiting for the signs of serious age-related diseases to appear, we mitigate risk factors and facilitate optimal health. Our focus is not to simply bring patients within the “normal” ranges found in traditional medicine. In many cases, these readings are not actually healthy at all, and are based on the overall U.S. adult population which encompasses the 32% of people who are obese. We therefore target accurate representations of optimal health, going far beyond age management medicine.

For example, we adhere to the highest standards in heart disease prevention with the understanding that 1 in 4 fatalities are caused by heart events. [1] More alarmingly, 50% of people who experience a heart event were classified as “low risk” by the measures employed in traditional medicine. [2] We use carotid artery testing to detect risk of heart attack or stroke by measuring the thickness of artery walls. In addition to this and other forms of sophisticated heart health testing which are not used in traditional medicine, we perform an abundance of additional exhaustive testing and diagnostics, including 86 comprehensive labs. This allows our physicians to drill down and identify core conditions causing health issues such as low energy or inability to lose weight. Even expert physicians who are highly trained in optimal health cannot properly diagnose a patient without this extensive testing, which also includes neurocognitive testing, VO2 max, DEXA scans, and more to precisely measure all biologic and physiologic biomarkers, as well as physical performance and mental acuity.

Additionally, it must be noted that age-related factors such as hormonal decline are not the only issues responsible for causing sub-optimal health. Exercise and sleep, for example, are cornerstones for reducing the risk of age-related problems including:

  • Obesity
  • Frailty
  • Dementia
  • Heart disease
  • Cancer
  • Osteoporosis

With the addition of hormone regulation, the effectiveness of nutrition, exercise, and sleep prescriptions can produce tangible results for motivated patients. Cenegenics patients therefore experience the benefits of hormonal health along with many more. Burning fat and building muscle, optimizing cognitive function, achieving quality sleep, and improving both physical and sexual energy are just a few of the lasting advantages of program participation. Ultimately, patients who choose Cenegenics understand that hormone replacement is of little value without establishing good overall health.

Clinics that offer hormone replacement therapy alone give patients only a small glimpse into their overall health. Yet, Cenegenics clinicians understand how each hormone has a specific job, but overlaps the others to create a synergistic environment for improved wellness.

Our team also realizes that hormone imbalances can encroach on job performance– especially in a 21st century business landscape where poor lifestyle choices, diminished endocrine system, and ongoing career-related stress can collide. Because hormones perceptively alter sexual, physical, and cognitive functions, which often lead to psychological complications, our team takes a sophisticated approach to wellness optimization instead of narrowly addressing a single parameter of age management. In doing so, we guide our patients into an improved lifestyle, maximizing health potential to enjoy a more youthful way of life with the following benefits:

Improved Energy

Cenegenics addresses the addition of exercise to a person’s regimen as research suggests that obesity is strongly linked to low testosterone, Cenegenics alternatives do not address exercise as their main focus is low testosterone and not the root causes of the issue

By the age of 70, roughly 30% of muscle mass individuals had at the age of 20 is gone [4]. This often contributes to decreased strength, fatigue, and energy depletion. Our age management doctors specialize in determining whether lifestyle changes alone are enough to address declining energy levels associated with aging, or whether a more aggressive approach is needed to target an underlying cause of the symptom.

Better Sleep

A low-T center does not focus on sleep, Cenegenics focuses on patients getting better sleep as poor sleep quality can attribute to hormonal changes, Cenegenics alternatives may not address sleep issues such as sleep apnea or disordered breathing as a cause of low testosterone

Untreated sleep disorders increase the risk of death from any cause in older adults [5]. More than a third of Americans are poorly rested for more days out of the week than not, and nearly half the population (46%) is unable to achieve the recommended seven to eight hours of sleep every night [6].

While poor sleep is in certain cases attributed to hormonal changes, there are many other potential culprits. Specifically, there is a proven interplay between sleep and inflammation, especially in the cardiovascular system. Sleep-disordered breathing and obstructive sleep apnea, in particular, can be attributed to sleep issues for at least 24% of the population. By addressing sleep disorders, in addition to any contributing factors, Cenegenics physicians make the greatest possible improvement on both long- and short-term health in their patients.

Mental Acuity

It is in irrefutable fact that the mind changes with age. Yet, neural and cognitive functions are complex, and age-related changes to brain structure and function are not the same in all individuals. Moreover, age alone isn’t the only factor impacting focus, memory, and other cognitive functions. Lifestyle factors such as exercise, sleep, diet, alcohol consumption, and even caffeine intake can all influence brain health. Understanding the ways in which these factors affect the mind demands an extensive look into an individual’s current measures of health, medical history, and lifestyle. Through approaches such as nutraceuticals and prescriptive lifestyle adjustments, Cenegenics clinicians advise tailored preventive treatment programs to help patients minimize age-related cognitive decline.

Weight Loss

Cenegenics focuses on weight loss for obese patients as it can be a large contributor of low T, Cenegenics alternatives do not often focus on weight loss as part of their treatment plan of low T

Metabolic rate drops by 2% or more per decade after the age of 25 [7], making weight loss and weight regulation more challenging with age. However, it is important to understand that aging, and the fluctuations in hormone levels that go with it, cannot be solely blamed for the obesity epidemic. It is instead eating patterns that contribute to obesity, which is directly linked to morbidity from heart disease, cancer, diabetes, and high blood pressure [7]. Thus, any indication that a single hormone supplement will accomplish weight loss in itself is a falsehood, as there is no way to achieve sustainable weight loss without compliance to a healthy eating program.

Cenegenics physicians take into consideration the lifestyle factors, preferences, and nutritional needs of their patients to design a detailed dietary plan. In doing so, they help their patients make the transition towards mindful, healthy eating habits that will last, instead of dieting. The results are not only reductions in body fat, but also decreased risk of life-threatening conditions such as cardiovascular disease.

Increased Libido

A declining sex drive can take a toll on overall wellbeing, as well as the quality of a relationship. Low sexual interest can stem from a multitude of factors, including fatigue. Like weight management and sleep, addressing variances in libido necessitates a patient-centric approach. Our physicians therefore perform a comprehensive analysis into overall physical and mental health to determine the best course of action for each patient.

Cenegenics alternatives focus on increasing testosterone in order to increase libido, Cenegenics focuses on additional factors like weight management and sleep as low libido may stem from a multitude of factors

Overall, the comprehensive approach taken by Cenegenics is vastly different from those of most low-T clinics, many of which promise results with a few simple steps. True health optimization requires compliance with a demanding and comprehensive program. Low-testosterone clinics, conversely, advertise services such as medications shipped to you after a brief analysis. Unfortunately, these quick and easy approaches may overlook some significant indicators of health – which could have serious consequences.

How Cenegenics Differs from a Low-T Center: Unwavering Attention to Detail

Cenegenics clinical team take an all-encompassing approach compared to Cenegenics alternatives, The Cenegenics team ranges from phlebotomists to physicians in order to give the highest quality of patient care

Cenegenics’ comprehensive approach to health encompasses patient care from multiple sources, including wellness optimization physicians, exercise physiologists, phlebotomists, and nutrition & nutraceutical experts. They also look at the entire picture of patient health by taking into consideration key factors such as carbohydrate metabolism to observe the ways in which bioidentical hormones are impacting critical bodily functions.

Individualized Treatment

One important difference among Cenegenics and its competitors is our commitment to prioritizing the individual needs analysis. Our care providers treat each patient based on the specific nuances and combined circumstances impacting their health. While we understand that symptoms associated with low hormone levels may be one of the primary reasons why patients seek us out, our physicians also understand that a “one size fits all” modality is ineffective for treating these conditions. Instead, the complex interplay among nutrition, exercise, sleep, and genetic factors, among others, must all be considered and accounted for when developing a robust and effective health optimization plan.

To administer such a plan, Cenegenics collects in-depth, comprehensive lab values on patients at specific intervals. Contrast this with low-T centers, many of which boast a simple and easy three-step process. After the patient contacts the center, physicians from these low-cost options typically only perform a review of the patient’s sex hormone panel before prescribing medications. Yet, this significantly limits the physician’s understanding of how hormones are directly affecting carbohydrate and lipid metabolism, inflammatory markers, and kidney and liver function. More alarmingly, they may fail to address the treatment’s potential influence on prostate health. While low-T centers may perform lab work when subjective symptoms arise, Cenegenics is proactive in measuring the impact of bioidentical hormone use on prostate, kidney, and liver health, as well as other biomarkers.

By processing this information and regularly observing patients and patients’ biomarkers, our clinical team dynamically shifts and adjusts nutrition, exercise, and supplement goals and efforts, as needed, as patients respond and adapt over time. This allows us to make recommendations based on the individual’s needs analysis and prescribe only what will impact their biomarkers.

The Biomarkers of Aging

Only trained age management specialists can perform a comprehensive analysis of an individual’s biomarkers of age and provide individualized treatment based on these factors. Unlike our chronological age, the biomarkers of aging tell a different story. Made up of parameters such as muscle strength, cardiovascular performance, bone density, immunology, and mental acuity, they give age management specialists the most comprehensive overview of wellness when combined. Using this information, Cenegenics clinicians are able to develop customized exercise, nutrition, and supplementation programs – in addition to bioidentical hormone treatment fitting the precise needs of the individual.

Industry-Leading Specialists

age management medical practice, Cenegenics physicians differ from low-t center centers

Many low-cost clinics operate under one physician, while Cenegenics boasts 20 centers across the country supported by Cenegenics Partners, Center Physicians and Fellows trained in Age Management Medicine by the AMM Education Foundation. As our Partner and Director of Education for the Clinical Strategies for Healthy Aging course, Dr. Jeffrey Park Leake also co-wrote the Textbook of Age Management Medicine, available on Amazon. We pioneered the world’s largest age management practice, and with a focus on preventive care, have helped more than 35,000 patients worldwide dramatically improve their health and vitality. With optimal health as our primary focus, we bridge the gap between medicine and scientifically-based prevention, going far beyond addressing hormonal imbalances and achieving maintenance, not just repair.

We also hold our physicians against the highest set of standards to ensure the utmost quality of care for our patients. These specialists are highly trained in Cenegenics clinical tactics to aging, and only 1% of trainees meet the requirements needed to become a Cenegenics Physician Partner. Our physicians collaborate on complex patient health issues and are continually receiving clinical updates as proven, evidence-based science evolves to ensure each patient’s program remains cutting-edge and effective. Patients can therefore remain confident in the fact that health issues which arise can be detected early for preventive treatment, and that continuous monitoring will ensure their individualized Program is consistently updated to reflect emerging science and evolving goals.

The value of having a full team of health optimization specialists oversee your needs and progress through the program is beyond measure: it ensures every aspect of your health is being enriched to its fullest potential. Additionally, with a complete panel of specialists, we do not outsource:

  • lab services
  • diagnostic testing
  • clinical support
  • pharmacy items
  • nutraceuticals

This means all of the components of your wellness program will be overseen by Cenegenics and managed internally. Instead of waiting in a lab office, you will receive prompt and professional service through our phlebotomy network. Instead of going to multiple locations for testing, diagnostics are performed onsite for your convenience. We also have employed, onsite support staff, versus call center or remote health coaches. Finally, our patients receive custom pharmacy items, and efficaciously dosed, pharmaceutically tested, nutraceuticals with patented raw materials – instead of low-cost, generic retail supplements. In other words, Cenegenics believes that the quality of what goes into the body directly influences the quality of health outcomes.

A Better Patient Experience Over Cenegenics Alternatives

Cenegenics patients often have a better overall patient experience as compared to a low-T center, Cenegenics unwavering attention to detail helps patients combat low testosterone and its symptoms

While the attention to detail within Cenegenics program versus its alternatives is perhaps the most noteworthy difference, one final factor to bear in mind is the patient experience. While there is nothing wrong with seeking treatment elsewhere, lower-cost alternatives typically require more effort on the patient end. As a concierge, proactive medical service, the Cenegenics team takes significant measures to ensure compliance with a demanding, comprehensive program to potentiate real results and manage age-related disease risk. Through timely follow-ups, patient-focused care from day one, and an unwavering commitment to your precise wellness needs, our team ensures a positive experience in your journey towards optimal health.

Why a Low-T Center Is Not an Alternative to Cenegenics

A search for “Cenegenics alternatives” yields thousands of results, ranging from Ehormones to HealthGAINS, Andrologix to Royal Medical Centers, and it is no surprise why. The world of age management medicine has exploded since the inception of our physician-founded program in 1997. Many hormone therapy services have emerged in response to the growing number of adults seeking out solutions for low hormone levels, promising a low-cost few step solution. However none compare to the original Age Management Medical Practice, Cenegenics.

Cenegenics focuses on attention to detail, taking significant measures to ensure compliance with a demanding, comprehensive program to potentiate real results and manage age-related diseases. The accessibility to the Cenegenics clinical team – physician, nutrition expert, exercise physiologist and phlebotomist, allows timely follow-up in patient focused care to guarantee you are receiving an individualized plan designed specifically to accommodate your needs; Cenegenics is not a “one-size-fits-all” program.

Next Steps to Prioritizing Your Health with Cenegenics

Register for your complimentary phone consultation.

We hope the information above assisted you in your research process.

Key Resources

This guide was produced with contributions from the following key resources:

[1] Centers for Disease Control and Prevention. “Heart Disease Facts”. Retrieved from

[2] From Vulnerable Plaque to Vulnerable Patient—Part III: Executive Summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force Report. The American Journal of Cardiology. 2006.

[3] Boston, Gabriella. “Basal metabolic rate changes as you age.” Washington Post. 05 March 2013.

[4] Dennis, Helen. “Successful Aging: Causes of energy loss in older adults.” Los Angeles Daily News. 29 June 2015.

[5] Paudel et al. “Rest/Activity Rhythms and Mortality Rates in Older Men: MrOS Sleep Study.” Chronobiology International. 06 Apr. 2010.

[6] Sleep and tiredness survey. YouGov. 02 June 2015.

[7] Stanford Health Care. Retrieved from URL:

Additional Information For Cenegenics Age Management Program 

What is Cenegenics?

What is Age Management Medicine?

What Does Cenegenics Cost?

Cenegenics Elite Health Program: Why You Should Consider Age Management Your Next Investment

Anti-Aging vs. Age Management

Weight Loss on the Cenegenics Age Management Program

Defy Your Age™ with Cenegenics

What is Testosterone Replacement Therapy (TRT)?

Symptoms of stress can range from anxiety to inability to focus, Chronic stress puts individuals at higher risk for cardiac episodes including heart attack and stroke

This Is How Your Body Is Reacting To Stress:

Stress impacts nearly every single system in the body. It can weaken the immune system, impede functionality in the digestive and reproductive systems, increase risk of cardiovascular disease, and accelerate aging.[1]

Optimal health is important to work performance, however – especially for professionals in high-power roles with many taxing responsibilities. When stress begins to affect cognitive function, including judgment, concentration, memory, as well as physical and emotional well-being, it becomes essential to address its impacts promptly. 

A healthy adaptational response to stress occurs over a short time frame. For minimal to no effects on long-term health, stress responses should be initiated quickly, maintained for a brief amount of time, and then turned off. On the other hand, problems arise when individuals experience an over-response to stress, or the stress response fails to shut off. A healthy response to stress is characterized by the following three steps:

  • The brain mediates the stressor, signaling the adrenal medulla to release adrenaline.
  • The hypothalamus, a region of the forebrain which coordinates the nervous system, works with the pituitary gland to trigger the slower maintenance response, signaling to the adrenal system to release hormones including cortisol.
  • Nerves react to the trigger, producing behavioral responses such as heightened awareness, focused attention, and reduced pain perception.

These actions controlled by the hypothalamic-pituitary-adrenal axis and sympathetic nervous system contribute to the body’s internal balance, or homeostasis, to optimize energy production and use. Because these systems influence other functions in the body; prolonged responses can have a damaging effect on health. [2]

Symptoms of stress can be both immediate and long-term. While there are many long-term consequences of chronic stress that should be considered to understand its full impact, for now, we will focus on short-term symptoms associated with the condition, categorized by type.

Physical Symptoms of Stress

The physical symptoms of stress can be experienced almost immediately upon exposure to stressors. Stress slows some bodily functions, such as the immune and digestive systems, while hastening others. For instance, blood pressure and pulse rate increase, and rapid breathing occurs.

Other physical effects of stress can include sweating, back or chest pain, muscle cramps or spasms, headache, nervous twitches, and upset stomach. Low energy, dry mouth, difficulty swallowing, ringing in the ear, and cold or sweaty hands and feet are also physical symptoms of stress. In cases of extreme stress, fainting can also occur.[3]

Cognitive Symptoms of Stress

Acute stress can be advantageous and allow individuals to be hyper alter and make quick decisions, Chronic stress can lead to difficulty concentrating and memory problems

Acute stress can heighten awareness, allowing individuals to become hyperalert to their surroundings . This can be advantageous in certain professional circumstances – allowing for sharp and quick decision-making, for example. Yet, chronic stress actually has the opposite effect. With constant worrying, anxiety, and racing thoughts, individuals may experience poor judgment.

Difficulty concentrating and memory problems are also common symptoms of chronic stress.[4] In professionals and executives, whose effectiveness in their role is largely determined by decision-making skills, the cognitive impacts of stress can take a devastating toll on one’s career.

Behavioral Symptoms of Stress

Behavioral symptoms of stress include negative habits such as nail biting and tobacco use to form, Chronic stress may lead individuals to turn to negative behaviors such as alcoholism and drug abuse

The negative impact of stress penetrates virtually every aspect of an individual’s life. In an attempt to escape stress factors, individuals often turn to unhealthy behaviors such as tobacco use, as well as drug or alcohol abuse. Over- or under-eating and decreasing frequency of exercise can also result from compounding stress.

Individuals may adopt nervous habits like nail biting and pacing, and they may also become socially withdrawn. Procrastination and neglect of important responsibilities are additional characteristics of chronic stress; as some individuals use avoidance as an unhealthy coping mechanism.[5]

These negative behaviors can transcend into other areas of one’s life, too. With unhealthy behavioral responses to stress, decisions to drink, use drugs, or practice other harmful habits may also affect sleep quality, weight, libido, energy, and cognitive function.

Optimizing these five areas of wellness is essential to job performance, because a well-rested individual who is also at their best both physically and mentally is better able to excel in their role. Therefore, the ability to deal with job-related stressors (or any other source of stress) in healthy, productive ways can support performance in the workplace, while also improving quality of life in one’s personal life, too.

Emotional Symptoms of Stress

Emotional symptoms of stress include increased agitation and may lead to social withdrawal, Chronic stress can progress into depression and other mental health conditions

The emotional symptoms of stress include anxiety and agitation, as well as feeling overwhelmed. Agitation can cause hostility, poor impulse control, tension, and uncooperativeness – qualities which sever ties among colleagues and other members of your professional network.[6]

Because individuals with chronic stress tend to limit their social interaction, they may also begin to develop feelings of isolation and loneliness. The condition may also lead to feelings of insecurity and restlessness. Feeling generally unhappy is a common symptom of stress, and over the long term, this can progress into depression and other mental health conditions.[7]

While these symptoms are serious and need to be addressed, the effects of stress become even more critical if not treated. Over the long-term, the consequences of ongoing stress can have an extreme impact on a person’s mental, physical, emotional, and cognitive wellness.

Impaired concentration and low energy levels are just two of the specific effects related to chronic stress that can directly diminish workplace performance. Cenegenics focuses on optimizing the five pillars of wellness – sleep, energy, libido, cognitive function, and weight management – with proven age management medicine to help professionals feel and perform their best professionally.

Long-Term Effects of Stress

Chronic stress has dangerous, multifarious implications: not only can stress create new problems, it may also exacerbate existing ones. For executives and professionals whose busy day-to-day routines are already impacted by the demands of juggling a multitude of responsibilities, the effects of chronic stress can be more pronounced than in the average individual.

The physical and mental toll the condition takes on people can ultimately transcend to the workplace, leading to conditions like lack of sleep, focus, and energy which can impede long-term goal achievement and overall career success. Here are just a few of the specific ways stress can have a lasting impact on health.

Physical Consequences of Long-Term Stress

The long-term physical effects of chronic stress are nearly too vast to measure. When stress is constant, the same life-saving response your body produces in acute stress can suppress your immune system, making you more vulnerable to disease and illness. 

Individuals with chronic stress are more prone to developing colds and other sicknesses, and there is even an established link between stress-related disorders and autoimmune diseases such as Crohn’s disease, rheumatoid arthritis, and psoriasis [8]. These conditions can lead to absenteeism and energy depletion, which could have a compounding, negative effect on work performance.

Researchers believe that when stress is severe, the body may lose control of cortisol over the immune system, contributing to increased inflammation. This can also lead to a range of serious health conditions, including heart disease, high blood pressure, and diabetes. Left untreated, these factors can contribute to potentially fatal conditions including heart attack and stroke [9].

Chronic stress can lead to increased risk of serious health conditions including heart disease and high blood pressure, Physical symptoms of stress can vary but may progress into potentially fatal conditions including heart attack and stroke

Stress can also impact physical appearance, leading to skin and hair issues including psoriasis, eczema, hair loss, and acne. When it affects diet and exercise, it may also lead to obesity or other eating disorders. Being overweight increases the risk of fatigue, as decreased sleep duration and quality are directly associated with increased body weight [10].

Thus, the effects of stress tend to snowball: fatigue also impairs brain activity, which makes it impossible to contribute to your fullest potential at work [11]. The inflammatory response can also irritate the colon, causing conditions such as gastritis and ulcerative colitis over time.

The impact of stress is so pronounced that it can even cause issues in the reproductive system. In women, it can cause menstrual problems, while it may cause sexual dysfunction such as premature ejaculation and impotence in men. Loss of sexual desire is also potential side effect of stress experienced in both men and women [12].

Additionally, while stress can contribute to obesity which can in turn cause fatigue, stress itself also often has a major impact on sleep. Unfortunately, the stress/sleep relationship often forms a dangerous cycle, in which the heightened state of alertness produced by chronic stress prevents sleep, but lack of sleep continues to cause added stress.

In fact, adults who sleep fewer than the recommended eight hours per night report a higher stress level than those who sleep at least eight hours each night. Stress often causes individuals to lie awake at night with anxiety, and this lack of sleep can compound the physical damage caused by stress. Even minimal sleep deprivation or poor sleep quality can contribute to serious health issues like obesity and high blood pressure, as well as impaired memory and judgment [13].

While alertness is essential to navigating daily challenges in most executive, managerial, and other professional roles, it is also necessary for a host of other day-to-day activities, including driving and maintaining awareness of your general surroundings.

Additional Consequences of Chronic Stress

Additional symptoms of stress include depression and chronic anxiety

Chronic stress
can contribute to clinical depression, chronic anxiety states, and addictive disorders. One of the main reasons the condition is so dangerous is because of its notorious snowball effect: it may only impact a few isolated areas of a person’s life at first, but these consequences tend to ripple outwards.

The example of stress’s effect on sleep above showcases this relationship: while chronic stress itself can cause impaired judgment, it can also cause lack of sleep, which has an additional impact on decision making abilities. Thus, the lasting consequences of stress are often too significant to measure, and instead of affecting an individual in a linear fashion, it often produces a far-reaching web of consequences. Oftentimes, it penetrates the most critical realms of wellness in profound ways, including sleep, energy, weight, libido, and cognitive function.

These very pillars are the foundation on which the Cenegenics program was built. By finding solutions to improve in these five realms, effective stress management becomes a natural byproduct. For example, Cenegenics tailored programs provide solutions catered to each individual’s needs for optimizing nutrition, achieving better sleep, and driving energy levels, which can be effective tools for managing stress.

Understanding Chronic Stress vs Acute Stress – In Conclusion

Stress can impact nearly every single system in the body, and professionals in high-power roles with many taxing responsibilities are at in increased risk. Physical symptoms of stress can be experienced almost immediately upon exposure to stressors. Cognitive symptoms of stress such as constant worrying, anxiety, and racing thoughts can lead to poor judgment.

In an attempt to escape stress factors, individuals often turn to unhealthy behaviors such as tobacco use, as well as drug or alcohol abuse. These behaviors can lead to emotional symptoms and even progress into depression and other mental health conditions.

Over the long-term, the consequences of ongoing stress can have an extreme impact on a person’s mental, physical, emotional, and cognitive wellness. Cenegenics helps individuals with effectively managing stress by optimizing the five pillars of wellness – sleep, energy, libido, cognitive function, and weight management – with proven age management medicine to help professionals feel and perform their best professionally.

Contact Cenegenics to find out how our personalized, physician-developed age management solutions can help you treat your stress before you suffer long-term effects.

Next Steps: Managing Stress with Cenegenics


Our world class physicians create a personalized plan to help you feel 10+ years younger. You'll be more energetic, lose weight, sleep better, have more libido, and think more clearly. Click below to schedule a free consultation with one of our physicians. It's quick + easy. 

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] Segal et al. “Stress Symptoms, Signs, and Causes.” HELPGUIDEORG INTERNATIONAL. July 2018. Retrieved from URL:

[2] Stöppler, Melissa Conrad, MD. “Stress.” Retrieved from URL:

[3] Nordqvist, Christian. “Why stress happens and how to manage it.” Medical News Today. 28 Nov. 2017. Retrieved from URL:

[4] Segal et al, see above.

[5] “Stress symptoms: Effects on your body and behavior.” Mayo Clinic. 28 April 2016. Retrieved from URL:

[6] “Understanding Agitation.” Depression and Bipolar Support Alliance. Retrieved from URL:

[7] Segal et al, see above.

[8] Song et al. “Association of Stress-Related Disorders With Subsequent Autoimmune Disease.” Journal of the American Medical Association. 19 June 2018. Retrieved from URL:

[9] “The Link Between Autoimmune Diseases and PTSD.” Retrieved from URL:

[10] Hargens, et al. “Association between sleep disorders, obesity, and exercise: a review.” Nature and Science of Sleep. 1 Mar. 2013. Retrieved from URL:

 [11] Tanaka, et al. “Effects of Mental Fatigue on Brain Activity and Cognitive Performance: A Magnetoencephalography Study.” Department of Physiology, Osaka City University Graduate School of Medicine. 01 Jul. 2015. px

[12] Karriem-Norwood, Varnada, MD. “Stress: Symptoms.” WebMD. 11 July 2017. Retrieved from URL:

[13] “Stress and Sleep.” American Psychology Association. Retrieved from URL:

[14] Song et al. “Association of Stress-Related Disorders With Subsequent Autoimmune Disease.” Journal of the American Medical Association. 19 June 2018. Retrieved from URL:

Understanding how to deal with stressors can help decrease your risk of health problems and tarnishing long-term wellness, Business professionals often experience different types of stress including acute stress that can progress to chronic stress when not managed properly

Understanding How to Deal with Stressors

Article at a Glance

  • Stress is the body’s natural response to threats, and it is important to be able to distinguish the way the body experiences the three main types of stress: acute, episodic acute and chronic stress.
  • Internal stress factors come from within and can be caused by unrealistic expectation, pessimism, uncertainty, and negative self-talk.
  • External stress factors can include being too busy, feeling unable to complete everything on time.
  • Chronic stress can result in impaired cognitive function, weight gain, and a number of unfavorable symptoms.

Stress is the body’s normal response to threats. Yet, while it affects everyone in at least one way, not all forms of stress are the same – or even healthy. For professionals in positions associated with high levels of stress, it’s especially important to recognize the differences among the ways in which the body experiences stress.

Different Types of Stress

There are three main types of stress, each of which elicits a unique response in the body:

  • Acute stress
  • Episodic acute stress
  • Chronic Stress

Acute Stress

The demands of the near future and recent past cause acute stress, the most common form of stress. Work deadlines, exhilarating experiences, and short-term dilemmas can all cause acute stress. This form of stress is fleeting and does not have the potential to do long-term physical damage. In fact, acute stress can actually be considered “good” stress, because it helps executives and professionals perform better in challenging scenarios. Whether it is preparing for an important meeting or thinking quickly to rectify an unexpected issue, the body responds to perceived threats with quicker breathing and pulse, allowing you to use more oxygen and increase activity to perform better.[1] The danger to your health and work performance does not occur until acute stress becomes chronic stress, which is discussed below.

Episodic Acute Stress 

Individuals who always seem to be “on the edge of their seats,” often labeled as “Type A” personalities, are most likely to have episodic acute stress. While these individuals often embody characteristics that help them excel in the workplace, including the ability to multitask well and a sense of competitiveness that can lead to goal completion, they also face a tremendous amount of stress because they juggle many responsibilities and are pressured by time constraints.[2]  Cardiologists have concluded that these individuals are much more likely to have heart disease and high blood pressure than others, and face difficulties in organizing self-inflicted demands and pressures. Because these barriers to health can negatively impact work performance, individuals facing episodic acute stress must find ways to manage their stressors in a healthy way to ensure long-term wellness.[3]

Chronic Stress

By nature, stress is supposed to be temporary. Once the body recovers from fight or flight mode, you should be able to recover physically: your heart rate should return to normal and muscles should relax. Yet, chronic stress occurs even when real, physical danger is not present. It happens when a person is never able to escape their causes of stress but stops seeking solutions. Sometimes, it may be caused by a traumatic experience. While people can become used to and even comfortable with chronic stress, its effects are long-lasting and detrimental to health. Chronic stress is the most harmful type of stress and can have a number of effects on your body, mood, and behavior. If action is not taken, this form of stress can create or worsen health problems, including limited concentration, inhibited sleep, and problems with personal relationships – all of which can eventually lead to energy depletion and poor performance in the workplace.[4]

Understanding How to Deal with Stressors: Identifying Stress Factors

Our fight or flight response is influenced by both external and internal factors. While both types can produce similar effects, they can also both be addressed and managed effectively. Understanding the differences between these two sources can help pinpoint your greatest sources of stress.

Internal Stress Factors

As their name suggests, internal stressors come from within. These stressors stem from an individual’s perception of themselves compared to where they think they should be in life. Internal stressors play a role in one’s ability to handle external sources of stress, which is why it becomes critically important to address any internal stressors, if present, first. Common internal stress factors include:

  • The inability to accept uncertainty
  • Rigid thinking
  • Inflexibility
  • Pessimism
  • Unrealistic expectations of perfectionism
  • Negative self-talk

External Stress Factors

Common external stress factors include:

  • Job-related stress
  • Major life changes
    • Death of a family member
    • Divorce
    • Retirement
  • Family problems and relationship difficulties
  • Being too busy
  • The feeling of being unable to get everything done

Unfortunately, this tends to be a common feeling among individuals holding demanding jobs or maintaining positions of power in the workplace. Because the stress associated with high-power positions is unavoidable for most career-oriented professionals, the solution for managing chronic stress lies in first addressing its effects. By overcoming fatigue, for instance, professionals can become sharper and more alert, and ultimately, more engaged and focused at work. Likewise, tackling many of the additional challenges that tend to accompany aging, such as cognitive impairment and weight gain, can also create a healthier individual who is better able to manage the stress of their career.

Ultimately, stress is different for each individual, and the factors which may elicit a response in one person may not affect another. Regardless of the stressor, however, chronic stress can produce a number of unfavorable symptoms in those who suffer from it. Thus, addressing its effects proactively – before they escalate and cause irreversible career or relationship damage – is critical for people who face chronic stress.

Impact of Acute & Chronic Stress: In Conclusion

Stress can affect people in various ways, but for professionals dealing with high levels of stress, it is especially important to recognize the type of stress you are undergoing and the effect it can have on your body. All types of stress, if not managed, are all capable of increasing your risk for health problems and tarnishing long-term wellness.

Our fight or flight response is influenced by both external stressors and internal stressors. Internal stressors stem from an individual’s perception of themselves, and it is important to address them first to be able to handle any external stress factors. External stressors include job-related stress, family problems, relationship issues, etc. If such effects are left unmanaged, there is potential for unfavorable symptoms and health-related consequences of chronic stress.

Cenegenics’ expert clinicians help you overcome high levels of stress by catering to the rigorous demands that life presents.  Each program is individually tailored to your specific needs and is designed to help mitigate stress, both immediately and over a long-term basis.

Next Steps: Get a Handle Your Stressors 

Register for your complimentary phone consultation.

We hope the information above assisted you in your research process.

Key Resources on Stress Management

This guide was produced with contributions from the following key resources:

[1] “5 Things You Should Know About Stress.” National Institute of Mental Health. Retrieved from URL:

[2] Tirado, Bernando, PMP. “Working With a Type A Personality.” Psychology Today. 30 Jan. 2012. Retrieved from URL:

[3] “Stress: The different kinds of stress.” American Psychological Association. Retrieved from URL:

[4] Nordqvist, Christian. “Why stress happens and how to manage it.” Medical News Today. 28 Nov. 2017. Retrieved from URL:

Additional Information on Stress Reduction

How Cenegenics Can Help Relieve Stress in Executives & Professionals

Symptoms and Long-Term Consequences of Stress

What is Age Management Medicine?

What is Cenegenics?

Defy Your Age™ With Cenegenics

Acute stress can be effective in certain situations such as preparing for large presentations or facing certain challenges within the workforce, long-term or chronic stress can have detrimental effects on your health

Are You Aware Of The Impact Stress Has?

Stress is the body’s natural response to threats or demands. In limited doses, stress is normal and even healthy. It is the automatic “fight-or-flight” reaction that helps executives and other professionals prepare for and perform well under critical circumstances, such as meeting tight deadlines or practicing quick and effective decision-making. Stress can also be the catalyst that helps us react quickly when needed, whether in traffic or when faced with danger.

Despite all of these benefits, stress has a bad reputation – and for good reason. While our fight-or-flight instinct may indeed be vital to our survival, stress that occurs on a continual basis (chronic stress) can have an adverse effect on health and performance. When your nervous system stops differentiating among real physical danger and perceived, emotional threats, stress begins to recur frequently. This spurs a vicious cycle in which emergency stress is easily activated and increasingly difficult to avoid.[1]

Impact of Stress

While there are many causes of stress, one of the most common is a person’s work life. As the World Health Organization states, “Pressure in the workplace is unavoidable due to the demands of the contemporary work environment.”[2] Research shows that organizational risk factors for stress include busy work schedules, pressing demands relating to specific tasks and roles, and the degree of an individual’s involvement in decision making, among others. Yet, this description applies to the majority of today’s professions, meaning that stress is not something that can be evaded but must instead be approached differently. Addressing the effects caused by stress can help professionals optimize their wellness; giving them the power to overcome daily challenges and perform better in the workplace. When its effects are simply ignored, however, all of this stress has a far-reaching impact: with its wide range of consequences, it’s estimated that the total cost of stress exceeds $300 billion for U.S. enterprises.[3] 

Far Reaching Impact of Chronic Stress

Of course, the impact of stress is more than just financial. Chronic stress can impact your productivity, mood, relationships, health, and ultimately, your quality of life. It tends to have far-reaching implications on some of the most important parameters of wellness, including sleep quality, energy levels, libido, cognitive function, and body weight. Symptoms of stress may not appear all at once; rather, they may creep up slowly and even begin to feel familiar. Unfortunately, even busy professionals and executives who recognize the signs of stress may feel as if they have no time to address these compounding effects. As their list of responsibilities continues to grow, their health is often put last, while work and other demands take top priority.

Cenegenics Approach to Stress Management

Ask your Cenegenics physician how to relieve stress and the best way to reduce stress, one of the best means to reduce stress is proper exercise

At Cenegenics, our age management program is designed with executives and professionals in mind. We cater to the rigorous scheduling requirements of our patients and provide practical solutions for mitigating stress and tackling its many consequences, both immediately and over a long-term basis. Moreover, we understand that the pressures associated with demanding professions are inevitable, but through effective stress management, executives and professionals can improve upon the key areas of health, such as low energy, poor sleep, and cognitive function, to boost career performance.

Addressing the far-reaching impacts of stress is where we excel. Through physician-led, tailored treatment programs, Cenegenics provides a roadmap for executives and professionals to improve wellness in the areas of cognitive function, libido, energy, sleep, and weight. Our approach to wellness is scientifically proven, research-based, and overseen by physicians specializing in age management who tailor each program to their patients’ unique needs. Additionally, our stress mitigation plans are all-encompassing to address all of the areas of your wellbeing stress can permeate. Targeted treatments such as individualized nutrition plans, exercise programs, and hormone replacement therapy (if needed) are employed to achieve lasting improvements in sleep quality and duration, cognition, libido, energy levels, and weight regulation.

Oftentimes, busy professionals do not realize the impact of stress in their lives until physical symptoms begin manifesting themselves. The good news is that it is never too late to begin overcoming stress, and by tackling it now, you can begin improving your health immediately. If you suspect that stress could be holding you back professionally or that it has impacted your quality of life in additional ways, take a moment to identify the types, causes, symptoms, and long-term effects of chronic stress to help you determine whether your health could be in jeopardy.

How to Relieve Stress with Cenegenics Elite Health

Exercise is one of the most effective ways to reduce stress, Custom nutritional and exercise planning is one of the many examples of how Cenegenics physicians can support health stress management practices

Tackling stress effectively requires a comprehensive approach. It is not a simple fix but instead demands a strategic treatment plan, as would any other medical condition. Nutritional planning to support the immune system and targeted exercise programs to benefit the mental and physical state are just some examples of how Cenegenics physicians can support healthy stress management practices, thereby leading to a more focused, healthy, and engaged professional.[4] 

Unfortunately, one of the reasons patients fail to overcome chronic stress is because most recommendations for mitigating stress leave too much room for guesswork. Busy professionals and executives need a precise plan that can be used to improve all aspects of their wellness, so that they are armed with an entirely new, healthy way to combat the effects of stress and approach the responsibilities and demands that would normally cause them stress in the first place. Cenegenics age management physicians deliver treatments and tactics used to improve mental focus, sharpness, strength, and sleep quality, helping patients restore their ability to work through life’s many challenges in a healthy manner and relieve stress.

stress free executive with team, professionals in office effectively managing stress, team of professionals managing stress

While the effects of chronic stress can go unnoticed and even become comfortable to those suffering from it, you were likely drawn to this guide because stress has impacted your life in one way or another. Do not allow stress to take its toll on your well-being, professional life, or relationships any longer. Contact Cenegenics to find out how our personalized, physician-developed age management solutions can help you address the stress factors you face in positive, productive ways and reverse the effects caused by chronic stress.

Reduce the Risk of Stress – In Conclusion

Stress is the body’s natural response to threats or demands and is normal and even healthy, in low doses. The automatic reaction helps executives and other professionals prepare for and perform well under critical circumstances. However, while our fight-or-flight instinct may indeed be vital to our survival, stress that occurs on a continual basis (chronic stress) can have an adverse effect on health and performance. Often times, during chronic stress, your nervous system stops differentiating real physical danger and perceived, emotional threats, and can spur a vicious cycle in which emergency stress is easily activated and increasingly difficult to avoid.

Tackling stress effectively requires a comprehensive approach, including nutritional planning to support the immune system, and an exercise program to benefit physical and mental states. Cenegenics age management physicians deliver treatments to improve mental focus, sharpness, strength, and sleep quality to help optimize patients’ well-being, professional life, and relationships by restoring patients’ ability to work through stress in a healthy manner.

Next Steps to Reduce Stress and Increase Effectiveness

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] Segal et al. “Stress Symptoms, Signs, and Causes.” HELPGUIDEORG INTERNATIONAL. July 2018. Retrieved from URL:

[2] “Stress at the workplace.” World Health Organization. Retrieved from URL:

[3] Brun, Jean-Pierre. “Work-related stress: scientific evidence-base of risk factors, prevention and costs.” Université de Laval. Retrieved from URL:

[4] Nordqvist, Christian. “Why stress happens and how to manage it.” Medical News Today. 28 Nov. 2017. Retrieved from URL:

Hormone levels decline at a much slower rate in men than in women and can result in a gradual onset of symptoms which is why the decline is often associated with aging, low testosterone has been linked to increased body fat

Understanding Hormone Replacement Therapy & Low Testosterone

Article at a Glance

  • Low testosterone can increase the risk of cardiovascular disease, osteoporosis, metabolic syndrome, obesity, and diabetes.
  • Testosterone deficiency can be treated by oral administration, topical gels, or injections.
  • Patients receiving testosterone replacement therapy should be monitored closely. Each patient absorbs and metabolizes testosterone at vary rates and adjustments may need to be made.

The male hormone testosterone plays a critical role in men’s health: it strengthens bones, builds muscle, and improves brain function and heart health. Testosterone also improves libido and energy levels. Yet, by their middle ages, most men begin to witness a decline in this important hormone. By the age of 30, hormone levels begin to drop by 1% to 3% annually; at age 50, this could amount to a 20% drop. These imbalances can penetrate every aspect of life, from physical wellbeing to personal life, job performance, and business success.

Typically, hormone levels in men decline at a much slower rate than in women. Thus, the effects of testosterone deficiency can come on gradually, which is one of the reasons it is so often mistakenly attributed to general aging. Energy depletion, for instance, is typically attributed to being a “normal” part of aging. In reality, it could point to low testosterone, also known as low T. There are many other similar symptoms which could be going unnoticed.

Yet, while declining testosterone levels are normal to some degree in men, that doesn’t mean they have to live with the symptoms they produce. From low libido to increased risk of mortality, a decline in this critical hormone can lead to a number of frustrating symptoms. The good news is that these challenges can now be addressed through hormone replacement therapy.

In this guide, we’ll explore the topic of low T to help you make informed health decisions tailored to your precise needs and expectations. We’ll begin by looking at some of the common symptoms of testosterone deficiency, and by the end of this guide, you will have a comprehensive understanding of how the condition can be treated effectively through modern medical solutions.

Increased Disease Risk of Low Testosterone

increased risk of diabetes due to low testosterone, man checking blood glucose levels for improvement after hormone replacement therapy

In addition to the tangible effects of low T, there is also some increased risk of serious diseases men face when experiencing a deficiency. As stated in The Textbook of Age Management Medicine: Volume 2, available on Amazonconditions associated with testosterone deficiency include cardiovascular disease, osteoporosis and related bone fractures, metabolic syndrome and obesity, diabetes, and frailty. By addressing the deficiency through medical treatment, men can minimize their risk for these serious conditions, thereby enjoying a better quality of life, as well as reduced healthcare costs as they age.

What Impacts Testosterone Levels?

pharmaceuticals used in hormone replacement therapy, pharmaceuticals used to treat testosterone deficiency

As we’ve established, a gradual and minor decline in testosterone is normal with aging. Yet, that leaves the question: what actually causes abnormally low T levels?

It’s important to understand that there are both primary and secondary causes of hypogonadism, the medical term for “male menopause” or “andropause.” Congenital defects, certain developmental conditions, and even stress could be to blame for low T. Testicular trauma and surgical procedures, radiation treatment or chemotherapy, alcoholism, obesity, and certain types of pharmaceuticals can also hasten the decline of testosterone.

Because there are so many potential causes for low testosterone levels, approaching the issue requires personalized testing to confirm the diagnosis, which brings us to our next section.

What are the Risks of Testosterone Treatment?

Unmonitored testosterone levels during hormone replacement therapy can increase risk of cardiovascular issues

Misinformation tends to circulate surrounding the risks of testosterone treatment. There are certain side effects associated with testosterone replacement therapy, but it’s critically important to put these effects into context. Testosterone treatment can raise red blood cell counts, for instance, but under the care of experienced physicians, any associated risk will be minimized through in-depth screenings and active monitoring. The risk of cardiovascular disease is also low and cannot be determined as a direct contraindication to testosterone replacement therapy. In a 2010 study of men using testosterone gel, some participants experienced serious cardiovascular issues such as heart attacks. [2] Yet, studies have not been able to establish a concrete link between testosterone replacement therapy and heart attack risk, and there are many other contributing factors, which need to be examined more closely any time cardiovascular issues are present. [8] Lifestyle management tactics should therefore be implemented by age management professionals to parallel treatments and effectively minimize any potential risk.

Questions of a link between prostate cancer and testosterone treatment have also been raised, but these have also been challenged. Evidence shows that risk of prostate cancer in a patient undergoing testosterone treatment is equal to or actually less than that for the general population, with the exception of patients who have a history of prostate cancer. Thus, appropriate patient selection by expert physicians again plays a role in minimizing any risk associated with treatment.

Some testosterone replacement candidates also wonder about the risk of additional side effects, such as breast enlargement and hair loss. Yet, it’s important to understand that genetics, stress, and other factors play a role in many of these side effects. Again, expert physicians can monitor for early warning signs of these potential side effects to take prompt action against them. For breast tissue enlargement, for instance, aromatase inhibitors such as Anastrozole can be implemented to counterbalance this effect. Hair loss can be treated with over-the-counter solutions such as Minoxidil.

What are Symptoms of Low Testosterone?

One of the reasons testosterone deficiency is so infrequently diagnosed is because many of its symptoms imitate those associated with other conditions. Additionally, as mentioned above, some are also simply attributed to aging. As explained in The Textbook of Age Management Medicine: Volume 2, available from Amazon, age and body mass index (BMI) are both directly correlated with testosterone deficiency rates, so it is often difficult to determine whether age or hormones are to blame for increases in body fat. With that said, it is estimated that up to 39% of men aged 40 and older are deficient in testosterone. [3]

According to Harvard Health Publishing, testosterone levels in men decline by roughly 1% to 2% beginning in the 40s. [6] Although these slight decreases are considered normal with aging, noticeable symptoms could point to a testosterone deficiency. Oregon Health and Science University urologist Jason Hedges, MD, PhD, notes that lack of interest in sex, along with many of the other symptoms accompanying drops in testosterone, are often perceived as just a part of aging, “but that’s a misconception.” A gradual decline in testosterone would not account for little to no interest in sex. Many other symptoms may be mirrored by other conditions. Instead of low T, these symptoms were often credited to high blood pressure, depression, and diabetes. Due to the increasing awareness surrounding testosterone deficiencies, medical experts are now beginning to see the condition as the root cause for many of these problems. [5]

Below, we highlight some of the most common symptoms caused by testosterone deficiencies.

It isn’t simply increased BMI that men with testosterone deficiency face. As mentioned in “9 Signs of Low Testosterone,” a article, a deficiency is specifically linked to increased body fat. Some also develop gynecomastia, or enlarged breast tissue, which is suspected to result from a hormonal imbalance between testosterone and estrogen. The article also highlights decreased bone mass, loss of muscle mass, fatigue, hair loss, low semen volume, and difficulties with erections as additional physical indicators of low T. [1]

Beyond the physical impact of low T, men may also experience mood changes relating to the condition. Testosterone plays an important role in many physical processes, but it can also influence mood and mental capacity. According to research, factors such as depression, irritability, and difficulty focusing can all impact men facing testosterone deficiency. Likewise, low sex drive is another indicator of a hormonal issue. [9]

How is Low Testosterone Diagnosed?

physician meeting with patient to discuss low testosterone, physician discussing hormone replacement therapy with testosterone deficient patient

In order for a diagnosis of a testosterone deficiency to be made, a combination of biochemical and clinical diagnostic criteria is required. Clinical symptoms of testosterone deficiency are typically what spur patients to seek medical treatment, thereby prompting physicians to pursue a laboratory investigation.

Diagnosis of Testosterone Deficiency by Measurement of Free Testosterone Levels

The Textbook of Age Management Medicine: Volume 2, explains that testosterone is measured in multiple ways. First, there is free testosterone (FT), which refers to the fraction of testosterone that actually enters cells. It accounts for roughly 1% to 2% of testosterone available. It can be measured via equilibrium dialysis, a process that takes place following the patient’s blood draw. Average total testosterone (TT) levels are 723.8 according to the Framingham Heart Study, with a standard deviation of 221.1. [3] Thus, the “normal” range is not within the 95% confidence interval of average as standard medicine and lab ranges suggest. We’ll address these substantial differences below.

Diagnosis of Testosterone Deficiency by Measurement of Total Testosterone

In addition to FT, there is also total testosterone (TT). This figure measures both FT and the amount of hormone bound to the protein albumin, which is active and therefore bioavailable in the body. In other words, while FT floats around independently in the blood, roughly half of the remaining testosterone is attached to the albumin protein. TT measures both the FT and the testosterone attached to proteins. This, too, can be measured via a blood draw. [7] While the average level of FT is 141.8, this, too, can vary widely from one patient to the next.[3]

The challenge with getting an accurate reading lies in the fact that even TT tests leave 40% to 70% of testosterone unaccounted for, because it is traveling with a protein called sex hormone binding globulin (SHBG). It is tightly bound to this protein and therefore is unavailable in the cells. Thus, a large portion of TT could be biologically inactive, and results of tests may be misleading. TT levels that are borderline low could represent a true deficiency; or, it could be a variation in SHBG levels. For this reason, FT is the most essential measurement in making the biochemical diagnosis of a testosterone deficiency.

Another problem with diagnosing testosterone deficiency is that there are some limitations in measuring the hormone. First, there are technical limitations: the quality of tests may vary among laboratories, especially since there are multiple ways to measure testosterone. While equilibrium dialysis for measuring FT is considered the gold standard of testing, calculated free testosterone is considered an adequate measure. However, it must be understood that the different approaches for measuring testosterone levels can account for variability in patient results.

In addition to technical limitations, there is also a host of inherent variations in testosterone levels that can impact a patient on a daily, or even hourly, basis. Total testosterone fluctuates significantly throughout the day, for example. For this reason, blood is typically drawn for testosterone tests between 7 and 10 a.m. Still, we must consider daily intra-patient variations in levels according to health status, age, fasting state, and sleep, among other factors.

Lastly, there is still no single consensus on the definition of “low” testosterone. The criteria depend on the standards adopted by the doctor and/or lab.

The factors described above present significant challenges to making an initial diagnosis. Thus, while FT and TT measurements are necessary for managing patients with symptoms of low T, as well as monitoring treatments, reference ranges should be used as guidelines – not absolute inclusion or exclusion criteria for a diagnosis. Signs, symptoms, and patients known to have high risk factors for low T should be heavily weighted in diagnosing a deficiency. The most effective way to get a diagnosis is therefore to seek input from expert physicianssuch as those trained in age management medicine. Test results should be interpreted in light of identifiable symptoms, and the physician should therefore be able to form a “big picture” view of the condition.

Men who are ideal candidates for seeking help from a specialist could have the symptoms described in the previous section, along with loss of body hair, hot flashes, insomnia, decreased energy, poor concentration and memory, reduced muscle bulk and increased body fat, and diminished physical or work performance.

How is Testosterone Deficiency Treated?

Luckily, testosterone treatments are available to combat the symptoms described above. Patients tend to notice significant improvements within just a few weeks. Yet, many understandably have questions before beginning treatment. Here are some of the most commonly addressed points regarding testosterone replacement therapy.

Is Testosterone Replacement Therapy Safe?

physicians review and monitor progress of hormone replacement therapy for low testosterone, physicians monitor changes in testosterone during hormone replacement therapy

In an article for WebMD, urologist Jason Hedges, MD, PhD confirms that testosterone treatment is safe, as long as patients are monitored carefully by specialists. Appropriate patient selection, safe administration, and expert supervision are all essential for minimizing potential risks. Patients will be closely monitored during the initial six months of treatment to adjust dosing to their specific absorption rate. Absorption rates for testosterone can vary dramatically, which is why frequent lab work is performed and reviewed by expert physicians in age management medicine.

Which Forms of Testosterone Replacement Therapy Are Available?

Testosterone therapy options have come quite a long way since they were first introduced in the 1930s. Patients currently have a comprehensive range of choices with small clinical differences in each. Here are some of the most common options available for testosterone replacement therapy.

Testosterone Replacement Therapy by Oral Administration

Man orally ingesting testosterone pill as part of low testosterone hormone replacement therapy, treating testosterone deficiency orally

Oral administration was one of the earliest forms of testosterone therapy. However, it was rendered ineffective when researchers realized that orally ingested testosterone was metabolized in the liver before reaching systemic circulation, resulting in zero bioavailability. The earliest forms of oral testosterone were also linked to liver toxicity. Since then, sublingual (under the tongue) applications were made available, but due to side effects such as change of taste and gum irritation, they are not recommended.

Testosterone Replacement Therapy with Topical Gels

Testosterone administration with gels and topical products during hormone replacement therapy, Addressing low testosterone with gel and topical product

Testosterone gels and topical products in general are not recommended for a number of reasons. They require daily use and it is therefore easier for patients to mistakenly miss doses. They are also notoriously unreliable, because it can be difficult to administer the proper dose and adequate levels are therefore hard to obtain. They are gooey on the skin and can therefore be easily transferred to family members and other individuals with whom the patient regularly comes into contact. They may also lead to skin irritation.

Testosterone Replacement Therapy with Injections

Addressing low testosterone with testosterone injection during hormone replacement therapy, testosterone injected as hormone replacement therapy treatment

Intramuscular injections of testosterone are typically administered on a weekly basis. Like other forms of treatment, patients undergoing testosterone injections should be monitored closely, as it could be linked with an increase in red blood cell count. With that said, they are a preferred option because they are among the least expensive forms of treatment and are hailed for their reliable delivery.

Testosterone Replacement Therapy with Under-the-Skin Implants

Injected microspheres, or under-the-skin implants, release testosterone into the body over both a steady state, as well as a transient accelerated initial “burst” release. Also sometimes referred to as “pellets,” this form of treatment must be carefully monitored because each patient has a significantly different absorption rate. Pellets can also be relatively painful and expensive. Additionally, because they are implanted beneath the skin, they may cause infection and scarring.

Is Testosterone Therapy the Right Solution for You?

One of the most significant benefits of testosterone replacement therapy is the significant reduction in all-cause mortality. Hypogonadal men treated with testosterone therapy experience reductions by as much as 50% compared with untreated men. Beyond being healthier overall, however, there are many specific benefits men can experience when opting to receive hormone replacement therapy.

For one, muscle strength improves among hypogonadal men across most age groups, and reduction in fat mass is also achieved with the help of testosterone therapy. Certain treatments may also help enhance fertility in couples trying to get pregnant.[4] Typical benefits increasingly supported by clinical science can include improved body composition, greater bone strength, a healthier cardiovascular system, and better sexual function.

happy couple sitting on couch at home, hormone replacement therapy can increase sex drive due to optimal testosterone levels

If you’ve experienced issues like lethargy, increased body fat, declining sex drive, reduced muscle strength, or any of the other symptoms described herein, you could be an ideal candidate for testosterone replacement therapy. Cenegenics physicians are thoroughly trained and experienced in identifying hormone imbalances and are the premier choice for treatment among men who qualify for this powerful form of therapy.

Based on an extensive, full day initial evaluation with extensive lab panels, Cenegenics physicians who are highly trained experts in age management medicine can offer customized, tailored hormone therapy, if needed. Treatments are administered as part of a comprehensive program of nutrition, exercise, and vitamin and hormone supplementation for each patient to achieve optimal health as they age. The result is not only a better quality of life, but also lowered disease risk and increased vitality through the middle-ages and beyond.

Hormone Replacement Therapy to Treat Low Testosterone – In Conclusion

Testosterone deficiency can cause men and women to experience lethargy, increased body fat, declining sex drive, reduced muscle strength & loss of muscle mass, and many other symptoms. These symptoms often go unnoticed in correlation to testosterone deficiency as it is viewed as a normal “sign of aging”.

Though there are many treatments to address testosterone deficiency including oral administration, topical gels, intramuscular injections and under-the-skin implants, it is important to find a program in which you will be monitored. How a patient metabolizes or absorbs testosterone differs significantly from patient to patient.

Cenegenics individualized programs address hormone replacement therapy, only when clinically indicated by your comprehensive blood analysis. Your therapy is individualized to meet your specific needs. And patients are monitored to ensure adjustments are made when necessary.

Get Started Now and See If You Are a Candidate for Hormone Replacement Therapy

Register for your complimentary consultation.

We hope the information above assisted you in your research.

Key Resources for Hormone Replacement Therapy to Treat Testosterone Deficiency

This guide was produced with contributions from the following key resources:

The Cenegenics Education and Research Foundation

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Available for purchase here

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Education Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.

Additional Information about Hormone Replacement Therapy at Cenegenics

What is Age Management Medicine?

What is Cenegenics?

Defy Your Age™ With Cenegenics

Anti-Aging vs. Age Management

Cenegenics Elite Health Now Offers State-of-the-Art Genetic Testing

Sources on Hormone Replacement Therapy

[1] “9 Signs of Low Testosterone.” Healthline. 24 July 2018. Retrieved from URL:

[2] Basaria, et al. “Adverse Events Associated with Testosterone Administration.” The New England Journal of Medicine. 08 July 2010. Retrieved from URL:

[3] Bhasin et al. “Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham heart study and applied to three geographically distinct cohorts.” Journal of Clinical Endocrinology and Metabolism. 2011 Jun 22.

[4] “Female Fertility: What’s Testosterone Got To Do With It? University of Rochester Medical Center. 03 March 2014. Retrieved from URL:

[5] McMillen, Matt. “Low Testosterone: How Do You Know When Levels Are Too Low?” WebMD. 31 Aug. 2016. Retrieved from URL:

[6] Sloan, Matthew. “Treating low testosterone levels.” Harvard health Publishing. 25 July 2018. Retrieved from URL:

[7] “Testing your testosterone: It’s tricky.” Harvard Health Publishing. Oct. 2012. Retrieved from URL:

[8] “Testosterone and the heart.” Harvard Health Publishing. March 2010. Retrieved from URL:

[9] Tsujimura, Arika. “The Relationship between Testosterone Deficiency and Men’s Health.” The World Journal of Men’s Health. 31 Aug. 2013. Retrieved from URL:

Cenegenics is the clinical leader in age management medicine, Cenegenics uses preventive care which begins with a comprehensive elite health evaluation, additional testing such as telomere or heart attack and stroke prevention program can be added for an additional cost, the cost of Cenegenics can vary based on location

Youth is a Feeling – Not a Number

Aging is aging, right? Conventional wisdom might say so.

From lower energy levels to chronic pain and loss of muscle tone, there are many symptoms older adults experience that are considered to be “just a part of aging.” Declining libido and weight management challenges are a few additional conditions people witness with age, and the common sentiment is that there isn’t much we can do about it.

This is simply not true. There is something you can do to take control of your health as you age: proactive age management. Based on science and proven by medical research, modern anti-aging solutions are powerful treatments used to improve the quality of life for individuals as they enter their senior years.

Cenegenics is the Defining Clinical Leader in Age Management Medicine

Founded in 1997, Cenegenics is recognized in the medical community for its pioneering work in age management medicine. Its physicians are the leading authorities in the field, with Jeffrey P. Leake, M.D., Senior Physician and Director of Education for Cenegenics having co-authored the Textbook of Age Management Medicine. This guide serves as the foundation for clinical practice and was written based on Dr. Leake’s decade of experience at Cenegenics.

The entire Cenegenics team is passionate about helping individuals navigate the challenges of aging with greater ease. Here are some compelling statistics to note:

  • 1 in 3 adults suffers from high blood pressure, while only 54% of these individuals are actively controlling it
  • 70% of adults are overweight, while 34% have obesity
  • 80% of adults have at least one chronic health condition, while 50% have two or more [2]

While these conditions are not exclusive to older adults alone, we do know that aging can exacerbate symptoms or make an individual more prone to developing them. We are living longer now and, as such, there is an increasing demand to provide older adults with the specialized care they need and deserve.

This is precisely what Cenegenics aims to do. We take age management a step further by providing personalized, physician-developed age management programs to Defy Your Age™, taking an all-encompassing approach to improving wellness. Read on to find out how our programs work, and to learn what our services can do for you.

Start with a Highly Comprehensive Full-Day Assessment

The starting point of the Cenegenics program is the most comprehensive preventive health evaluation in the industry. It goes far beyond many well-known “Executive Health” evaluations, digging deep to establish as thorough a representation of a person’s health as possible. The testing includes:

1. Medical History and Lifestyle Assessment

Are you always tired? Have you struggled to lose weight and tone as aging progresses? Perhaps you're experiencing hormone problems or seeking ways to improve sex drive. No matter which health issues you're facing, the Cenegenics team wants to hear about it.

During the lifestyle assessment, you’ll provide information about your day-to-day living habits, including activity levels and eating patterns. You will also be asked to provide details about any noteworthy health issues, procedures, or other experiences you have to formulate a well-rounded overview of your medical history. This information will help the specialists shape a highly personalized program according to your unique needs.

2. Comprehensive Labs

The extensive lab panel measures a broad range of health indicators, including: CBC (complete blood count), evaluations on hormone levels, cardiac disease risks, lipid panels, homocysteine levels, potential prostate issues (in men), and urine analysis, among others. The results will reveal markers for disease risk and low hormone levels below the healthy range, which our programs can restore. It will also provide the opportunity to address any underlying conditions, if needed.

3. Physical Evaluation

When is the last time you received a full physical exam? Fewer than a quarter of all visits to family physicians are from older adults [1], which suggests that seniors aren’t seeking out preventive health care services as often as they should be. The ability to catch potentially life-threatening illnesses early on lies in routine physical examinations. The Cenegenics staff is adept at performing comprehensive, efficient exams.

Beyond drawing attention to serious health issues, physicals also provide medical experts the opportunity to take vital signs and spot any abnormalities which may have otherwise gone unnoticed. The findings from your physical will also factor into your comprehensive age management plan.

4. Dual Energy X-Ray Absorptiometry (DEXA)

The number we see on the scale only tells us one thing about our bodies. Calculating body composition, however, is far more involved than that. A number of complex factors contribute to our bodily makeup, which is why we use state-of- the-art DEXA scanning to measure:

  • Lean muscle mass
  • Body fat percentage
  • Bone mineral density
Woman in bright orange shirt laying on DEXA machine as doctor operates mechanics via computer

Each Cenegenics center offers a series of comprehensive scans that provide the most accurate measurements of bone and cardiometabolic health to help specialists develop a data-driven approach to clinical treatment. If you have a condition such as poor bone health, for instance, it can be analyzed quickly, allowing you to receive an initial treatment plan tailored specifically for you upon your first physician visit. Additional risk factors are assessed that correlate with visceral body fat levels, including diabetes, cardiovascular disease, and metabolic syndrome.

5. Cardiopulmonary Exercise Testing – CPET

Woman taking a VO2 max test on a bike while being monitored by an exercise physiologist

If you’re suffering from a lack of energy, this test could yield significant insights as to why. A VO2 Max test will measure your volume of oxygen consumption by assessing your ability to perform sustained exercise at maximum exertion. If there is an obstacle getting in your way of pursuing a weight loss program through fitness, this may be the test to help uncover it. It is generally considered the best indicator of cardiovascular fitness and aerobic endurance.

VO2 Max Results allow us to design a program that will help:

  • Maximize fat burning potential based on the best way to lose weight for your body type
  • Condition the heart to become stronger both during physical activity and periods of rest
  • Improve exercise efficiency to help you achieve powerful results

6. Carotid Artery Ultrasonography – Carotid Intima-Media Thickness (CIMT) Exam

Woman in green shirt looking at ceiling while getting an ultrasound of her carotid taken.

The carotid arteries (there are actually two – one on either side of the neck) supply blood to the brain, making this artery branch one of the most important systems in the body. A clinical examination of the arteries can uncover important evidence of conditions, leading to diagnosis and treatment. Inflammation of the artery, for instance, could point to an autoimmune disorder or previously undetected infection. Weakness and bulging in the artery can also indicate a number of ailments, which upon further investigation, may be treated effectively.

The CIMT Test is an FDA-approved, noninvasive advanced ultrasound evaluation of the carotid arteries. This evaluation allows for detection of existing plaque and provides a highly precise measurement of the thickness of the artery wall. Thickening of the artery wall is an early sign of vascular disease and relates to your risk of heart attack as well as stroke. Early detection allows for the formulation of proactive strategies to reduce your risk for these catastrophic events.

7. Neurocognitive Assessment

neurocognitive assessment chart showing scale of memory, processing speed, executive function, reaction time and complex attention.

One critical aspect of age management is maintaining – and in some cases, even strengthening – cognitive abilities. We begin to experience cognitive decline as early as our mid-twenties, with the decline in thinking and reasoning skills, memory impairment, and a decreased ability to maintain focus and solve problems becoming more pronounced thereafter [3].

While cognitive decline is indeed a scientifically proven aspect of aging, that isn’t to say that there’s nothing that can be done about it. Through our computerized cognitive assessment, CNS Vital Signs, we are able to evaluate important brain functions including memory, processing speed, executive function, and many other vital activities. Once on the Cenegenics program, patients often witness a significant improvement in cognitive performance. This is because our age management solutions are not focused on one area of health exclusively; instead, we firmly believe that supporting both the mental and physical aspects of well-being are essential to overcoming age-related challenges.

8. Core strength and flexibility assessment

If you’ve ever embarked on a weight loss program, you know that eating a balanced diet and maintaining physical fitness are the best ways to lose weight. While strength and flexibility are not the only markers of vitality, they are considered important measures of fitness. By assessing your current fitness levels, the Cenegenics team will be able to forge a comprehensive strategy to help you reach your goals.

9. Comprehensive exercise and nutrition assessment

Many individuals who enter the Cenegenics program want to know how to lose weight quickly. A better question would be: How can I lose weight in a way that’s sustainable for my lifestyle? With an in-depth assessment, we will unlock the answers to this question. With that said, the program will still provide enough challenge, forcing the body to adapt, spurring noticeable results.

10. Food Allergy & Immunology Testing*

An analysis of diet-induced sensitivity pathways provides individual insights into inflammation-provoking foods and food chemicals specific to your body’s own response, which could be interfering with your health goals. Food sensitivities and allergies are commonly perceived as initiating minor, temporary symptoms. Unfortunately, not all symptoms are recognizable and, more frustratingly, many symptoms associated with food allergies can be attributed to other issues.

Something as seemingly innocent as gluten could be creating a chronic inflammatory reaction within your body, causing you to experience persistent discomfort and acting as a barrier against your wellness goals. More specifically, a spike in white cells caused by an allergy can have a pro-inflammatory and pro-algesic mediator release. It is the interplay between these pro-algesic mediators (cytokines, histamines, and prostaglandins) and analgesic mediators that causes inflammatory pain. Left untreated, high levels of pro-algesic mediators can have a chronic inflammatory response which can develop into both short-term conditions and long-term disease. Our specialized diagnostics are used to assess these levels, helping our clinical team derive data-driven insights that can factor into your wellness strategy.

11. Micronutrient Analysis*

Although needed only in small amounts, micronutrients play a vital role in a number of key bodily functions, including: hormone production, immune function, enzymatic function, and metabolism of glucose, fatty acids, and amino acids. Micronutrients are also needed to support general cell replication and repair – two factors which are critical to fighting the effects of aging. By understanding micronutrient imbalances within your system, we can identify any risk factors that could contribute to degenerative diseases, balance deficiencies that could otherwise hinder anti-aging treatment, and gain further insights into common complaints related to specific diseases.

12. Genomic Testing*

Have you ever wondered why some people seem more susceptible to health conditions than others? Many risk factors have a lot to do with our genetics. Our comprehensive exome sequencing measures all 22,000 genes of your DNA and cross-references them with more than 100,000 health-related findings on cancer, cardiovascular disease, cognitive function, potential prescription drug complications, and various chronic diseases. In doing so, we can determine which types of treatments will be safest and most effective based on your genetic profile. Measurements of this degree outperform traditional genome sequencing tests, which only look at partial snippets of your DNA and cannot pinpoint the rare genetic mutations that 10% of Americans have [4].

13. Telomerase Testing*

Father and son playing with a football in the park

Telomeres are an essential part of human cells that affect cellular aging. They also protect critical information of our DNA. When telomeres are abnormally short, they are linked to premature cellular aging. By understanding your percentage of short telomeres, we are able to prioritize critical lifestyle changes, as well as nutraceutical selection, to improve the telomerase enzyme for healthier, longer telomeres.

14. Genetic Inflammatory Biometric Testing*

Biometric testing sounds complex, but it can be broken down rather simply. Since “bio” refers to living things and “metrics” is simply another word for measurements, genetic inflammatory biometric testing is just a phrase that describes the measurement of your inflammatory reactions based on genetic factors. Here are three of the main testing types we use to uncover these insights:

  • KIF6: Genotype that determines if specific cardiovascular medications are useful to the individual
  • ApoE: Genotype that determines response to dietary fat
  • 9p21: Genotype that determines risk of early onset heart attack, abdominal aortic aneurysm, and total heart disease risk

15. Cardiovascular Biomarkers*

When the heart is damaged or stressed, it releases substances called cardiac biomarkers into the bloodstream. Measuring these markers can help determine whether or not there is sufficient blood flow to the heart, among other critical functions. Here are some of the biomarkers Cenegenics can test:

  • Myeloperoxidase: Potential inflammatory precursor to myocardial infarction
  • High-sensitivity C-reactive protein: Measure for systemic inflammation
  • Microalbumin:creatinine ratio: Data suggests subjects with elevated microalbumin levels have a 3x greater risk of developing heart disease [5]
    • F2-isoprostane:creatinine ratio – Gold Standard in measuring oxidative stress

Watch this video to learn more about the comprehensive evaluation:

Exercise counselor discussing results of DEXA scan with patients.

*Available at additional charge

Custom Designed Cenegenics Age Management Program

What Can I Expect from the Cenegenics Program?

Each patient consults with their Cenegenics physician for several hours to develop an in-depth understanding of health issues and risks based on the results of their lab and diagnostic analysis, medical history, and lifestyle assessment. The patient will then work collaboratively with their Cenegenics physician to develop an individualized, goal-oriented plan that suits their lifestyle and food and exercise preferences. All nutraceutical supplements and, if medically indicated, hormone supplementation will be prescribed by the Cenegenics physician. The patient will be closely monitored during follow-up lab analysis to ensure optimal dosages, as each patient’s body will absorb supplements at different rates, and adjustments can be made to reach optimal levels.

The Cenegenics Difference: Personalized Care

Each patient is different, and that is why a “one-size-fits-all” or “take this supplement” approach will routinely fail. Some patients prefer playing tennis over going to the gym to work out, for instance. For these individuals, we custom-design exercise programs to supplement tennis playing. This maximizes efforts and eliminates redundancies, thereby delivering a comprehensive result for healthy aging.

Likewise, nutrition is highly complex and medically different for each individual (we'll explore this in greater detail in an upcoming section). There is no such thing as a patient who eats a "perfect" diet.

With this in mind, the Cenegenics team works with patients to develop a customized nutrition plan that works for them which they can implement with ease into their lifestyle. Many of our patients are busy executives who travel often and do not have optimal food choices available, so we create a workable system. One simple Cenegenics weight loss tactic is to swap a starch for two sides of vegetables when dining out. Of course, this is just one example to showcase the level of personalization each patient receives when pursuing their wellness journey; there are many more physician-approved weight loss strategies that can be leveraged by individuals across all circumstances. These strategies can also be coupled with tactics like individualized fitness programs and nutraceuticals, if needed.

Cenegenics Weight Loss Programs: Better Understanding the Role of Nutrition and Exercise

Healthy nutritional fruits and vegetables on white background

Nutrition and exercise are integral components of our robust age management programs. Here, we’ll take a look at why Cenegenics gets results when other weight loss alternatives you may have tried fell short.

Nutrition & Weight Loss Programs: More than Just Calories 

Nutrition is a very important modifiable element in aging well. It sounds simple but it is not. Nutrition is a complex, polyvalent system encompassing an interplay of hormones, genomics, hedonics, energy balance, and macronutrients. Understandably, it can become very overwhelming for an individual to conceptualize the relationship between all of these moving parts, and how mastering this balance can help them lose weight.

The nutritional prescription, therefore, should be written like any other treatment for conditions such as heart disease or diabetes: based on individual needs analysis. The interplay referred to above is patient-specific, and the nutrition plan must recognize this. By carefully reviewing the nutrition-related biomarkers via blood and genomic testing, Cenegenics prioritizes which markers are playing the most detrimental role in your health, and then develops a plan of attack based on these factors.

In some individuals, for example, carbohydrate metabolism and the ability to utilize the body’s primary source of fuel can decline over many years. In certain cases, this could be a result of poor nutritional choices. Others may learn that they have genetic markers that prevent them from breaking down seemingly healthy foods appropriately, and instead their bodies respond via inflammation. Identifying these issues and developing a nutritional strategy that progresses and changes as the individual reduces their risk factors and becomes healthier is critical to long-term success.

Lose Weight & Tone with the Cenegenics Approach to Exercise

Now, let’s talk about exercise. Unfortunately, it’s impossible to exercise your way to significant fat reductions alone. However, when combined with an optimized eating program, exercise is key to aging well. Like diet, exercise must be patient-specific, comprising the proper mix of aerobic, resistance, flexibility, and balance training.

Too often, we get caught in the moment, seeking short-term solutions on how to lose weight quickly. We may succumb to fitness and exercise trends that are promoted in magazines, on television, and across social media. These programs are often presented as fail-proof and as the “ideal” form of exercise. Oftentimes, the lack of results that eventually ensues can create a perpetual sense of failure.

It is therefore critically important to understand that there is no “one-size-fits-all” approach to exercise, either. However, by incorporating metabolic testing and measuring the body’s ability to deliver oxygen to all of its working muscles, Cenegenics identifies your body’s most ideal starting point and pushes you to the appropriate intensities that you are physically capable of achieving, while also allowing for sufficient recovery. The use of scientific, evidence-based exercise allows you to see results from month-to-month, building your confidence and motivation while preventing injury.

A Pillar of Cenegenics Success: Close Monitoring and Consultation

While the evidence-based science and the experience of Cenegenics physicians remains unmatched, another key difference of the Cenegenics program that delivers results for our patients is our close monitoring and consultation. Patients receive unlimited consultations with their full Cenegenics clinical team, including a Cenegenics age management doctor and clinical specialists in nutrition and exercise.

New patients often engage in a weekly dialogue with their clinical team to discuss progress, experience, and how they are feeling so modifications can be made, as needed, to optimize the program. The Cenegenics physician will prescribe ongoing lab work to closely monitor the body’s response to the custom-prescribed nutraceuticals and hormone supplementation, if needed, and make adjustments accordingly.

Patients will have an annual reevaluation so that we can closely monitor and manage their progress towards their healthy aging goals and identify any emerging risk factors for proactive intervention.

Does Cenegenics Work?

Proven Results

Cenegenics has had over 35,000 patients on its programs. We are highly trusted within the medical community, as 25% of our patients are physicians and their families.

Based on an internal study, our average patient reduced their body fat index by 30% in the first year on the Cenegenics program**.

You can see what our patients are saying about their Cenegenics experience:

Cenegenics - Patient Testimonial - Look at the ResultsAnthony Maffei, MD, FACS, Cenegenics Patient

Dr. Maffei discussing his experience on the Cenegenics program. Mature male in grey shirt standing against white background.

Cenegenics - Patient TestimonialJonny Bowden, PhD, CNS, Cenegenics Patient

Dr. Jonny Bowden discussing Cenegenics Elite Health Programs, mature man in suit standing against white background

**Based on internal study of the last 200 Cenegenics patients completing their first annual re-evaluation, the average body fat percentage declined 30% from the initial extensive evaluation when joining the Cenegenics program.

Are You Ready to Live a Healthier, More Active Life?

Register for your complimentary phone consultation.

We hope the information above assisted you in your research process.

About the Senior Cenegenics Physician, Dr. Leake

Dr. Jeffrey Leake sitting outside. Mature male in white shirt sitting in park

Dr. Leake, a board-certified anesthesiologist, educated at Ohio State University, held a 23-year tenure at Washington's Harrison Medical Center Bremerton as Chief of Anesthesiology and Medical Director of Surgical Services.

An expert in nutrition and physiology, Dr. Jeffrey Park Leake has long been known for guiding patients in a preventive health approach. As course instructor for the Age Management Medicine Education Foundation (AMMEF), he demonstrates the established Cenegenics model for achieving optimal health and youthful aging.

He is a certified personal trainer and avidly pursues backcountry/extreme skiing, equestrian sports, weight, plyometric and yoga training. He is a member of the Endocrine Society, North American Menopause Society, International Menopause Society, American College of Sports Medicine, American Society for Nutrition and the National Strength and Conditioning Association.

He is the author of the Textbook of Age Management Medicine and was the recipient of the Alan P. Mintz Award for Excellence in Age Management Medicine in 2015.

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] American Family Physician,, 2018.

[2] Centers for Disease Control,, 2018.

[3] Deformation Field Morphometry Reveals Age-Related Structural Differences between the Brains of Adults up to 51 years, The Journal of Neuroscience, 2008.

[4] Global Genes®,, 2015.

[5] Urinary albumin excretion in a population based sample of 1011 middle aged non-diabetic subjects, Scandinavian Journal of Clinical and Laboratory Investigation, 1993.