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VO2 Max Testing is one of the most significant tests when analyzing a patient’s ability to utilize oxygen, The results of the VO2 Max will help your Cenegenics clinical team determine the best fitness program for you

See Why Cenegenics Is The Gold Standard Of Men’s Health With The VO2 Max Testing Machine

One of the unique advantages of Cenegenics’ Age Management program is the comprehensive testing performed by our clinical team. With a full panel of age management experts, we thoroughly screen each patient to achieve as robust a measurement of overall wellness as possible. While each test we perform holds tremendous value in terms of directing our physicians in developing an individualized program, one of the most significant parameters analyzed is a patient’s ability to utilize oxygen during exercise. This is measured through VO2 max testing.

Importance of VO2 Max Testing at Cenegenics

VO2 max testing assesses the maximal oxygen consumption of an individual during periods of intense, strenuous exercise. It is currently considered to be the gold standard of measuring cardiovascular fitness among medical experts and is hailed for its ability to accurately assess cardiorespiratory functioning.

Not only does this test indicate aerobic fitness levels of a specific individual, it also provides a wealth of useful information on which specific directions can be provided for training purposes. Additionally, VO2 max testing unlocks powerful insights into overall wellness, including warnings of potential cardiac or respiratory disease symptoms.

At Cenegenics, VO2 max testing is a primary component of each Elite Health Evaluation, and our clinical team uses the results of this test to create your individualized program for optimal results.

What is VO2 Max Testing? 

VO2 Max Testing at Cenegenics, Exercise room with VO2Max Test cycling equipment

There are various ways to perform a VO2 max test, the most common including use of a treadmill or cycle ergometer, both of which measure energy expenditure. Through the treadmill method, the participant begins by walking on a treadmill at a 10% grade.

Every two minutes, both the treadmill’s speed and grade will increase until a maximal work output or volitional failure is achieved. While this is considered to be the most thorough means of testing, as it requires the use of the entire body, it also presents significant risk of injury.

This is a maximal exercise test that is intended to push participants to reach levels of exhaustion, which, on a treadmill, can lead to the risk of falling. The proper precautions must therefore be implemented to ensure the safety of participants.

As an alternative to the treadmill test, the cycle ergometer is used as a safer option. At Cenegenics, we perform VO2 max tests via cycle as it is a much more efficient and less dangerous method for our clients. Additionally, it still provides valid, valuable results and information.

How Does a VO2 Max Test Measure?

A VO2 max test employs the use of a mask, which is worn by the participant during the exercise and connected to a metabolic cart where biometric measurements are recorded. As the participants breathe, the air is collected in a mixing chamber where the gas is analyzed.

When the air enters the chamber, both the volume of air and the ratio of carbon dioxide to oxygen are measured. The testing system uses specialized software, which can determine the energy expenditure of the exercise.

As the level of exercise intensity increases, the amount of carbon dioxide expelled while breathing also increases. These readings allow physicians to determine which fuel sources are being used in the body, (fats or carbohydrates) during a given point of time throughout the test. This proves to be beneficial for assigning customized training values for patients.

How to Read VO2 Max Test Results

Our cutting-edge VO2 max software provides a host of extremely useful information. Here, we will discuss the practicality and application of the data derived from the testing.

One of the most outstanding qualities of this test is its ability to track all of the following data in 15-second intervals for the duration of the entire test, allowing our physicians to observe not only the changes that occur but also how quickly physiologic markers shift as the exercise intensity increases.

Relative and Absolute VO2 Max

Absolute VO2 max (L/min) is a total value, while relative VO2 max (ml/kg/min) takes body weight into consideration. The relative value is therefore a more precise indicator of overall health than the absolute value.

For example, an individual may have a high absolute value, but when factoring in body weight, it is determined that they have a very low relative value which indicates less than ideal health. See the below chart for Relative VO2 Max Norms from the American College of Sports Medicine.

METS identify the amount of oxygen consumed at rest, graph of metabolic equivalent ranges for men and women

Metabolic Equivalents (METS)

Also known as metabolic equivalents, METS identify the amount of oxygen consumed at rest. One MET is defined as 3.5 ml/kg/hour, which is equivalent to the energy cost of sitting idly. This measurement provides a simple and straightforward means of measuring exercise intensity via oxygen consumption, and may be particularly beneficial for training.

Most treadmills now have a feature that will display the METS of a certain intensity level. An exercise physiologist or similar professional may prescribe an exercise plan using METS as a frame of reference for appropriate levels of intensity during physical activity.

Carbon Dioxide Expelled (VCO2)

VCO2 (L/min) is a value that goes hand-in-hand with VO2. As exercise intensity increases, so too does oxygen consumption (VO2). Thus, as more oxygen is consumed, more CO2 is created and expired through breathing.

The volume of carbon dioxide expelled after transporting oxygen throughout the body is measured by VCO2. CO2 is also created as a byproduct of energy production inside the body during rigorous exercise; we will cover that in greater detail in an upcoming section.

Ventilation (VE)

VE (L/min) refers to ventilation. In simpler terms, VE defines the movement of air via breathing. Ventilation therefore increases with exercise intensity, as the need to supply the body with oxygen and remove carbon dioxide increases. VE can also be correlated with the ventilatory threshold (described below) and used for training purposes

Tidal Volume (VT)

VT (L) is tidal volume. It is the volume of air that is transported into and out of the lungs with each respiratory cycle or breath. As exercise intensity increases, a larger oxygen demand is placed on the working tissue, demanding a larger volume of air per breath, more breaths per minute and an increased heart rate.

Respiratory Rate (RR)

Respiratory rate, or RR, is measured in breaths per minute. At rest, an adult averages 12 to 20 breaths per minute. As activity intensifies, respiratory rate will increase. With that said, elite athletes have the ability to maintain a lower RR even while performing high-intensity exercise, due to optimal cardiovascular conditioning.

Heart Rate (HR)

Heart rate (HR) is measured in beats per minute (bpm). Increased exercise intensity requires an increased oxygen demand to the body. In order to meet that demand, heart rate must increase to facilitate the transportation of oxygen to the working muscles. Both resting and exercising heart rate can be influenced by factors such as medication, stress levels, hormones, weight, and fitness level.

Most individuals have a resting heart rate between 60 and 100 bpm, but trained athletes may have a resting HR as low as 40 bpm. In general, physicians tend to recommend a target heart rate during moderate exercise of roughly 50-70% of maximum HR, or 70-80% of maximum HR during vigorous exercise. Keep in mind that maximum heart rate may vary by age and other factors, so physician oversight is essential to ensuring patients are exercising within safe HR zones [1].

Respiratory Exchange Ratio (RER)

RER stands for respiratory exchange ratio. It is among the most valuable pieces of information derived from a VO2 max test. RER determines the ratio of CO2 to O2 used, and it is indicative of the fuel source being used by the body. RER operates on a scale of 0.7 to upwards of 1.0, with 0.7 indicating utilization of fats for fuel and a measure of 1.0 or higher designating use of carbohydrates. This can be determined by the amount of CO2 in the air exhaled by the subject.

During periods of rest, we utilize fats as a fuel source and would therefore have an RER of 0.7. This is because breaking fat down for fuel requires oxygen and time. It is a slow process, so while at rest or during low-intensity exercise, our bodies are able to get enough oxygen to break down fats for fuel.

As exercise intensity increases, however, the body is no longer able to break down fats quickly enough to provide energy. It therefore needs to pull from carbohydrates stored in the muscles, known as glycogen stores. Carbohydrates require little oxygen to be broken down as fuel, and compared to breaking down fats, the process is completed fairly quickly.

As more carbohydrates are utilized to keep up with energy demands, however, fewer fats are used. The RER will then begin to shift up to 1.0. Typically, around the 1.0 mark the individual is anaerobic, meaning energy production depends fully on carbohydrates and there is a lack of oxygen to create energy.

Why Do a VO2 Max Test?

Man cycling for cardiovascular health, Vo2 Max Testing is the most effective predictor of long term health

With all of the aforementioned data points provided by a VO2 max test, participants are provided with a better understanding of their overall health, potential disease risk factors, and fitness levels. The VO2 max test is one of the most effective predictor methods of long-term health and significant disease risk – so much so, in fact, that the American Heart Association (AHA) has released a statement on the reliability of cardiorespiratory fitness (synonymous with VO2 max) as an effective indicator of health risk factors.

Additionally, emerging evidence is increasingly linking low VO2 max values with high risk of cardiovascular disease and all-cause mortality. It is even proving to be a more dependable indicator than other risk factors, including smoking, hypertension, diabetes, and high cholesterol.

When evaluating overall health, the relative VO2 max and METS are the values of most importance. The relative value provides an accurate determination with oxygen consumption levels with regards to weight, which provides greater insight into an individual’s overall wellness. Meanwhile, per the AHA, METS can be used as an indicator of high-risk mortality, with a measure of less than five indicating high risk, and a METS of 8 to 10 associated with a better chance of survival.

woman running to improve her cardiovascular health, Vo2 Max Test helping woman shape her training plan to further improve fitness and health

Not only does VO2 testing accurately assess health, but it also measures overall fitness levels and provides practical information, in order to prescribe precise training plans to further improve fitness and health. While not all exercise equipment or fitness trackers have the ability to analyze VO2, one of the best ways to apply this data to an individualized training program is by using a common, accessible value such as heart rate (HR).

Most modern exercise equipment, fitness trackers, and smartphones have the ability to measure heart rate and provide the user with instant feedback. By using heart rate as a method of prescribing exercise, patients can match a heart rate zone to a desired intensity to elicit a specific result.

How, precisely, is this done? If a lower training intensity or steady-state cardiovascular exercise is ideal for the patient’s need, the physician would match the RER of roughly 0.85 to the patient’s respective heart rate value and recommend that they stay in that range.

Likewise, if high-intensity interval training (HIIT) would best support the patient’s goals, the physician would recommend a heart rate value that could be achieved in accordance with an RER of 1.1. (If not 1.1., the patient might aim for the highest value over 1.0 prior to cooling down). That heart rate value is the target HR to shoot for when doing HIIT to achieve an anaerobic state, which ensures the full benefits of this style of training are realized. If the heart rate is too low, on the other hand, there may be insufficient stimulus to truly achieve the benefits of HIIT training.

Maximizing Results at Cenegenics with VO2

At Cenegenics, we do not simply use VO2 max testing as a means of assessing health; we also use the data derived from the test to continuously support a demanding, comprehensive program to potentiate real results and minimize risk factors for age-related disease. After completing a VO2 max assessment at a Cenegenics facility, the patient’s data is then analyzed by an age management physician, as well as a qualified exercise and nutrition counselor, and used to assess risk and develop a training program created exclusively for that individual.

Using the aforementioned process and associating heart rate values with target RERs, a target heart rate zone will be prescribed as a goal to reach during exercise. By working within this target range, the patient will achieve anaerobic exercise and stimulate the EPOC response.

EPOC stands for excess post-exercise oxygen consumption, which refers to the period of time following physical activity during which the body uses oxygen to generate adenosine triphosphate (ATP), clear out lactate, return normal oxygen flow to the rest of the body, and restore the body temperature to a normal level. During this time frame, the body will be more metabolically active and continue to burn additional calories as a result. HIIT training is the most effective way to achieve EPOC, whether through running, rowing, biking, or using resistance exercise.

Man performing HIIT training on track, Man sprinting during HIIT training workout

HIIT training involves short bursts of exercise performed at an all-out intensity level, typically lasting from 10 to 30 seconds, followed by a short 45 to 60 second rest period. These durations vary based on fitness level. For instance, after a five-minute warmup, a HIIT routine might involve a 15-second max sprint followed by a 45-second rest, repeated for a total of ten minutes and followed by a five-minute cool down.

In just 20 minutes, the amount of work done and caloric expenditure can exceed that of a 30 to 45 minute low-intensity steady state workout. It is for this reason that HIIT is widely recommended by Cenegenics physicians and favored by Cenegenics patients.

The results of using VO2 max testing to prescribe exercise programs and implement wellness measures to lower disease risk speak for themselves. Cenegenics patients are not only better able to achieve their weight loss goals and maintain their results; they are also more energized, alert, and healthier overall. If you are interested in discovering the power of VO2 max testing firsthand, contact your nearest Cenegenics location today.

Key Resources

This guide was produced with contributions from the following key resources: 

Textbook of Age Management Medicine Volume 1:

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook of Age Management Medicine Volume 2

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] “Know Your Target Heart Rates for Exercise, Losing Weight and Health.” American Heart Association, Inc. 2018. Retrieved from URL: http://www.heart.org/en/healthy-living/fitness/fitness-basics/target-heart-rates

Cenegenics is the clinical leader in age management medicine, Cenegenics uses preventive care which begins with a comprehensive elite health evaluation, additional testing such as telomere or heart attack and stroke prevention program can be added for an additional cost, the cost of Cenegenics can vary based on location

Youth is a Feeling – Not a Number

Aging is aging, right? Conventional wisdom might say so.

From lower energy levels to chronic pain and loss of muscle tone, there are many symptoms older adults experience that are considered to be “just a part of aging.” Declining libido and weight management challenges are a few additional conditions people witness with age, and the common sentiment is that there isn’t much we can do about it.

This is simply not true. There is something you can do to take control of your health as you age: proactive age management. Based on science and proven by medical research, modern anti-aging solutions are powerful treatments used to improve the quality of life for individuals as they enter their senior years.

Cenegenics is the Defining Clinical Leader in Age Management Medicine

Founded in 1997, Cenegenics is recognized in the medical community for its pioneering work in age management medicine. Its physicians are the leading authorities in the field, with Jeffrey P. Leake, M.D., Senior Physician and Director of Education for Cenegenics having co-authored the Textbook of Age Management Medicine. This guide serves as the foundation for clinical practice and was written based on Dr. Leake’s decade of experience at Cenegenics.

The entire Cenegenics team is passionate about helping individuals navigate the challenges of aging with greater ease. Here are some compelling statistics to note:

  • 1 in 3 adults suffers from high blood pressure, while only 54% of these individuals are actively controlling it
  • 70% of adults are overweight, while 34% have obesity
  • 80% of adults have at least one chronic health condition, while 50% have two or more [2]

While these conditions are not exclusive to older adults alone, we do know that aging can exacerbate symptoms or make an individual more prone to developing them. We are living longer now and, as such, there is an increasing demand to provide older adults with the specialized care they need and deserve.

This is precisely what Cenegenics aims to do. We take age management a step further by providing personalized, physician-developed age management programs to Defy Your Age™, taking an all-encompassing approach to improving wellness. Read on to find out how our programs work, and to learn what our services can do for you.

Start with a Highly Comprehensive Full-Day Assessment

The starting point of the Cenegenics program is the most comprehensive preventive health evaluation in the industry. It goes far beyond many well-known “Executive Health” evaluations, digging deep to establish as thorough a representation of a person’s health as possible. The testing includes:

1. Medical History and Lifestyle Assessment

Are you always tired? Have you struggled to lose weight and tone as aging progresses? Perhaps you're experiencing hormone problems or seeking ways to improve sex drive. No matter which health issues you're facing, the Cenegenics team wants to hear about it.

During the lifestyle assessment, you’ll provide information about your day-to-day living habits, including activity levels and eating patterns. You will also be asked to provide details about any noteworthy health issues, procedures, or other experiences you have to formulate a well-rounded overview of your medical history. This information will help the specialists shape a highly personalized program according to your unique needs.

2. Comprehensive Labs

The extensive lab panel measures a broad range of health indicators, including: CBC (complete blood count), evaluations on hormone levels, cardiac disease risks, lipid panels, homocysteine levels, potential prostate issues (in men), and urine analysis, among others. The results will reveal markers for disease risk and low hormone levels below the healthy range, which our programs can restore. It will also provide the opportunity to address any underlying conditions, if needed.

3. Physical Evaluation

When is the last time you received a full physical exam? Fewer than a quarter of all visits to family physicians are from older adults [1], which suggests that seniors aren’t seeking out preventive health care services as often as they should be. The ability to catch potentially life-threatening illnesses early on lies in routine physical examinations. The Cenegenics staff is adept at performing comprehensive, efficient exams.

Beyond drawing attention to serious health issues, physicals also provide medical experts the opportunity to take vital signs and spot any abnormalities which may have otherwise gone unnoticed. The findings from your physical will also factor into your comprehensive age management plan.

4. Dual Energy X-Ray Absorptiometry (DEXA)

The number we see on the scale only tells us one thing about our bodies. Calculating body composition, however, is far more involved than that. A number of complex factors contribute to our bodily makeup, which is why we use state-of- the-art DEXA scanning to measure:

  • Lean muscle mass
  • Body fat percentage
  • Bone mineral density
Woman in bright orange shirt laying on DEXA machine as doctor operates mechanics via computer

Each Cenegenics center offers a series of comprehensive scans that provide the most accurate measurements of bone and cardiometabolic health to help specialists develop a data-driven approach to clinical treatment. If you have a condition such as poor bone health, for instance, it can be analyzed quickly, allowing you to receive an initial treatment plan tailored specifically for you upon your first physician visit. Additional risk factors are assessed that correlate with visceral body fat levels, including diabetes, cardiovascular disease, and metabolic syndrome.

5. Cardiopulmonary Exercise Testing – CPET

Woman taking a VO2 max test on a bike while being monitored by an exercise physiologist

If you’re suffering from a lack of energy, this test could yield significant insights as to why. A VO2 Max test will measure your volume of oxygen consumption by assessing your ability to perform sustained exercise at maximum exertion. If there is an obstacle getting in your way of pursuing a weight loss program through fitness, this may be the test to help uncover it. It is generally considered the best indicator of cardiovascular fitness and aerobic endurance.

VO2 Max Results allow us to design a program that will help:

  • Maximize fat burning potential based on the best way to lose weight for your body type
  • Condition the heart to become stronger both during physical activity and periods of rest
  • Improve exercise efficiency to help you achieve powerful results

6. Carotid Artery Ultrasonography – Carotid Intima-Media Thickness (CIMT) Exam

Woman in green shirt looking at ceiling while getting an ultrasound of her carotid taken.

The carotid arteries (there are actually two – one on either side of the neck) supply blood to the brain, making this artery branch one of the most important systems in the body. A clinical examination of the arteries can uncover important evidence of conditions, leading to diagnosis and treatment. Inflammation of the artery, for instance, could point to an autoimmune disorder or previously undetected infection. Weakness and bulging in the artery can also indicate a number of ailments, which upon further investigation, may be treated effectively.

The CIMT Test is an FDA-approved, noninvasive advanced ultrasound evaluation of the carotid arteries. This evaluation allows for detection of existing plaque and provides a highly precise measurement of the thickness of the artery wall. Thickening of the artery wall is an early sign of vascular disease and relates to your risk of heart attack as well as stroke. Early detection allows for the formulation of proactive strategies to reduce your risk for these catastrophic events.

7. Neurocognitive Assessment

neurocognitive assessment chart showing scale of memory, processing speed, executive function, reaction time and complex attention.

One critical aspect of age management is maintaining – and in some cases, even strengthening – cognitive abilities. We begin to experience cognitive decline as early as our mid-twenties, with the decline in thinking and reasoning skills, memory impairment, and a decreased ability to maintain focus and solve problems becoming more pronounced thereafter [3].

While cognitive decline is indeed a scientifically proven aspect of aging, that isn’t to say that there’s nothing that can be done about it. Through our computerized cognitive assessment, CNS Vital Signs, we are able to evaluate important brain functions including memory, processing speed, executive function, and many other vital activities. Once on the Cenegenics program, patients often witness a significant improvement in cognitive performance. This is because our age management solutions are not focused on one area of health exclusively; instead, we firmly believe that supporting both the mental and physical aspects of well-being are essential to overcoming age-related challenges.

8. Core strength and flexibility assessment

If you’ve ever embarked on a weight loss program, you know that eating a balanced diet and maintaining physical fitness are the best ways to lose weight. While strength and flexibility are not the only markers of vitality, they are considered important measures of fitness. By assessing your current fitness levels, the Cenegenics team will be able to forge a comprehensive strategy to help you reach your goals.

9. Comprehensive exercise and nutrition assessment

Many individuals who enter the Cenegenics program want to know how to lose weight quickly. A better question would be: How can I lose weight in a way that’s sustainable for my lifestyle? With an in-depth assessment, we will unlock the answers to this question. With that said, the program will still provide enough challenge, forcing the body to adapt, spurring noticeable results.

10. Food Allergy & Immunology Testing*

An analysis of diet-induced sensitivity pathways provides individual insights into inflammation-provoking foods and food chemicals specific to your body’s own response, which could be interfering with your health goals. Food sensitivities and allergies are commonly perceived as initiating minor, temporary symptoms. Unfortunately, not all symptoms are recognizable and, more frustratingly, many symptoms associated with food allergies can be attributed to other issues.

Something as seemingly innocent as gluten could be creating a chronic inflammatory reaction within your body, causing you to experience persistent discomfort and acting as a barrier against your wellness goals. More specifically, a spike in white cells caused by an allergy can have a pro-inflammatory and pro-algesic mediator release. It is the interplay between these pro-algesic mediators (cytokines, histamines, and prostaglandins) and analgesic mediators that causes inflammatory pain. Left untreated, high levels of pro-algesic mediators can have a chronic inflammatory response which can develop into both short-term conditions and long-term disease. Our specialized diagnostics are used to assess these levels, helping our clinical team derive data-driven insights that can factor into your wellness strategy.

11. Micronutrient Analysis*

Although needed only in small amounts, micronutrients play a vital role in a number of key bodily functions, including: hormone production, immune function, enzymatic function, and metabolism of glucose, fatty acids, and amino acids. Micronutrients are also needed to support general cell replication and repair – two factors which are critical to fighting the effects of aging. By understanding micronutrient imbalances within your system, we can identify any risk factors that could contribute to degenerative diseases, balance deficiencies that could otherwise hinder anti-aging treatment, and gain further insights into common complaints related to specific diseases.

12. Genomic Testing*

Have you ever wondered why some people seem more susceptible to health conditions than others? Many risk factors have a lot to do with our genetics. Our comprehensive exome sequencing measures all 22,000 genes of your DNA and cross-references them with more than 100,000 health-related findings on cancer, cardiovascular disease, cognitive function, potential prescription drug complications, and various chronic diseases. In doing so, we can determine which types of treatments will be safest and most effective based on your genetic profile. Measurements of this degree outperform traditional genome sequencing tests, which only look at partial snippets of your DNA and cannot pinpoint the rare genetic mutations that 10% of Americans have [4].

13. Telomerase Testing*

Father and son playing with a football in the park

Telomeres are an essential part of human cells that affect cellular aging. They also protect critical information of our DNA. When telomeres are abnormally short, they are linked to premature cellular aging. By understanding your percentage of short telomeres, we are able to prioritize critical lifestyle changes, as well as nutraceutical selection, to improve the telomerase enzyme for healthier, longer telomeres.

14. Genetic Inflammatory Biometric Testing*

Biometric testing sounds complex, but it can be broken down rather simply. Since “bio” refers to living things and “metrics” is simply another word for measurements, genetic inflammatory biometric testing is just a phrase that describes the measurement of your inflammatory reactions based on genetic factors. Here are three of the main testing types we use to uncover these insights:

  • KIF6: Genotype that determines if specific cardiovascular medications are useful to the individual
  • ApoE: Genotype that determines response to dietary fat
  • 9p21: Genotype that determines risk of early onset heart attack, abdominal aortic aneurysm, and total heart disease risk

15. Cardiovascular Biomarkers*

When the heart is damaged or stressed, it releases substances called cardiac biomarkers into the bloodstream. Measuring these markers can help determine whether or not there is sufficient blood flow to the heart, among other critical functions. Here are some of the biomarkers Cenegenics can test:

  • Myeloperoxidase: Potential inflammatory precursor to myocardial infarction
  • High-sensitivity C-reactive protein: Measure for systemic inflammation
  • Microalbumin:creatinine ratio: Data suggests subjects with elevated microalbumin levels have a 3x greater risk of developing heart disease [5]
    • F2-isoprostane:creatinine ratio – Gold Standard in measuring oxidative stress

Watch this video to learn more about the comprehensive evaluation:

Exercise counselor discussing results of DEXA scan with patients.

*Available at additional charge

Custom Designed Cenegenics Age Management Program

What Can I Expect from the Cenegenics Program?

Each patient consults with their Cenegenics physician for several hours to develop an in-depth understanding of health issues and risks based on the results of their lab and diagnostic analysis, medical history, and lifestyle assessment. The patient will then work collaboratively with their Cenegenics physician to develop an individualized, goal-oriented plan that suits their lifestyle and food and exercise preferences. All nutraceutical supplements and, if medically indicated, hormone supplementation will be prescribed by the Cenegenics physician. The patient will be closely monitored during follow-up lab analysis to ensure optimal dosages, as each patient’s body will absorb supplements at different rates, and adjustments can be made to reach optimal levels.

The Cenegenics Difference: Personalized Care

Each patient is different, and that is why a “one-size-fits-all” or “take this supplement” approach will routinely fail. Some patients prefer playing tennis over going to the gym to work out, for instance. For these individuals, we custom-design exercise programs to supplement tennis playing. This maximizes efforts and eliminates redundancies, thereby delivering a comprehensive result for healthy aging.

Likewise, nutrition is highly complex and medically different for each individual (we'll explore this in greater detail in an upcoming section). There is no such thing as a patient who eats a "perfect" diet.

With this in mind, the Cenegenics team works with patients to develop a customized nutrition plan that works for them which they can implement with ease into their lifestyle. Many of our patients are busy executives who travel often and do not have optimal food choices available, so we create a workable system. One simple Cenegenics weight loss tactic is to swap a starch for two sides of vegetables when dining out. Of course, this is just one example to showcase the level of personalization each patient receives when pursuing their wellness journey; there are many more physician-approved weight loss strategies that can be leveraged by individuals across all circumstances. These strategies can also be coupled with tactics like individualized fitness programs and nutraceuticals, if needed.

Cenegenics Weight Loss Programs: Better Understanding the Role of Nutrition and Exercise

Healthy nutritional fruits and vegetables on white background

Nutrition and exercise are integral components of our robust age management programs. Here, we’ll take a look at why Cenegenics gets results when other weight loss alternatives you may have tried fell short.

Nutrition & Weight Loss Programs: More than Just Calories 

Nutrition is a very important modifiable element in aging well. It sounds simple but it is not. Nutrition is a complex, polyvalent system encompassing an interplay of hormones, genomics, hedonics, energy balance, and macronutrients. Understandably, it can become very overwhelming for an individual to conceptualize the relationship between all of these moving parts, and how mastering this balance can help them lose weight.

The nutritional prescription, therefore, should be written like any other treatment for conditions such as heart disease or diabetes: based on individual needs analysis. The interplay referred to above is patient-specific, and the nutrition plan must recognize this. By carefully reviewing the nutrition-related biomarkers via blood and genomic testing, Cenegenics prioritizes which markers are playing the most detrimental role in your health, and then develops a plan of attack based on these factors.

In some individuals, for example, carbohydrate metabolism and the ability to utilize the body’s primary source of fuel can decline over many years. In certain cases, this could be a result of poor nutritional choices. Others may learn that they have genetic markers that prevent them from breaking down seemingly healthy foods appropriately, and instead their bodies respond via inflammation. Identifying these issues and developing a nutritional strategy that progresses and changes as the individual reduces their risk factors and becomes healthier is critical to long-term success.

Lose Weight & Tone with the Cenegenics Approach to Exercise

Now, let’s talk about exercise. Unfortunately, it’s impossible to exercise your way to significant fat reductions alone. However, when combined with an optimized eating program, exercise is key to aging well. Like diet, exercise must be patient-specific, comprising the proper mix of aerobic, resistance, flexibility, and balance training.

Too often, we get caught in the moment, seeking short-term solutions on how to lose weight quickly. We may succumb to fitness and exercise trends that are promoted in magazines, on television, and across social media. These programs are often presented as fail-proof and as the “ideal” form of exercise. Oftentimes, the lack of results that eventually ensues can create a perpetual sense of failure.

It is therefore critically important to understand that there is no “one-size-fits-all” approach to exercise, either. However, by incorporating metabolic testing and measuring the body’s ability to deliver oxygen to all of its working muscles, Cenegenics identifies your body’s most ideal starting point and pushes you to the appropriate intensities that you are physically capable of achieving, while also allowing for sufficient recovery. The use of scientific, evidence-based exercise allows you to see results from month-to-month, building your confidence and motivation while preventing injury.

A Pillar of Cenegenics Success: Close Monitoring and Consultation

While the evidence-based science and the experience of Cenegenics physicians remains unmatched, another key difference of the Cenegenics program that delivers results for our patients is our close monitoring and consultation. Patients receive unlimited consultations with their full Cenegenics clinical team, including a Cenegenics age management doctor and clinical specialists in nutrition and exercise.

New patients often engage in a weekly dialogue with their clinical team to discuss progress, experience, and how they are feeling so modifications can be made, as needed, to optimize the program. The Cenegenics physician will prescribe ongoing lab work to closely monitor the body’s response to the custom-prescribed nutraceuticals and hormone supplementation, if needed, and make adjustments accordingly.

Patients will have an annual reevaluation so that we can closely monitor and manage their progress towards their healthy aging goals and identify any emerging risk factors for proactive intervention.

Does Cenegenics Work?

Proven Results

Cenegenics has had over 35,000 patients on its programs. We are highly trusted within the medical community, as 25% of our patients are physicians and their families.

Based on an internal study, our average patient reduced their body fat index by 30% in the first year on the Cenegenics program**.

You can see what our patients are saying about their Cenegenics experience:

Cenegenics - Patient Testimonial - Look at the ResultsAnthony Maffei, MD, FACS, Cenegenics Patient

Dr. Maffei discussing his experience on the Cenegenics program. Mature male in grey shirt standing against white background.

Cenegenics - Patient TestimonialJonny Bowden, PhD, CNS, Cenegenics Patient

Dr. Jonny Bowden discussing Cenegenics Elite Health Programs, mature man in suit standing against white background

**Based on internal study of the last 200 Cenegenics patients completing their first annual re-evaluation, the average body fat percentage declined 30% from the initial extensive evaluation when joining the Cenegenics program.

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About the Senior Cenegenics Physician, Dr. Leake

Dr. Jeffrey Leake sitting outside. Mature male in white shirt sitting in park

Dr. Leake, a board-certified anesthesiologist, educated at Ohio State University, held a 23-year tenure at Washington's Harrison Medical Center Bremerton as Chief of Anesthesiology and Medical Director of Surgical Services.

An expert in nutrition and physiology, Dr. Jeffrey Park Leake has long been known for guiding patients in a preventive health approach. As course instructor for the Age Management Medicine Education Foundation (AMMEF), he demonstrates the established Cenegenics model for achieving optimal health and youthful aging.

He is a certified personal trainer and avidly pursues backcountry/extreme skiing, equestrian sports, weight, plyometric and yoga training. He is a member of the Endocrine Society, North American Menopause Society, International Menopause Society, American College of Sports Medicine, American Society for Nutrition and the National Strength and Conditioning Association.

He is the author of the Textbook of Age Management Medicine and was the recipient of the Alan P. Mintz Award for Excellence in Age Management Medicine in 2015.

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] American Family Physician, aafp.org, 2018.

[2] Centers for Disease Control, cdc.gov, 2018.

[3] Deformation Field Morphometry Reveals Age-Related Structural Differences between the Brains of Adults up to 51 years, The Journal of Neuroscience, 2008.

[4] Global Genes®, globalgenes.org, 2015.

[5] Urinary albumin excretion in a population based sample of 1011 middle aged non-diabetic subjects, Scandinavian Journal of Clinical and Laboratory Investigation, 1993.

man with abs smiling after successful weight loss program, Cenegenics helps man achieve his long term weight loss goals

How Cenegenics Programs Differ from a Typical Weight Loss Program

Weight loss has become a priority for a growing portion of the population. According to the CDC, more than a third of U.S. adults are considered obese, while a whopping 70% of adults are considered overweight.[1]

In addition, while many people seek out weight loss programs for aesthetic reasons, the impact of excess body fat extend far beyond appearance alone. Dangers of being overweight include increased risk for developing serious health issues, including Type 2 diabetes, hypertension, cardiovascular disease, fatty liver disease, and even certain types of cancer.[2]

It is therefore no surprise that an increasing number of individuals are pursuing weight loss goals to look and feel better. The only problem is that many approaches are built on flawed diets, or the belief that exercise routines alone can achieve sustained weight loss. To further complicate the matter, adults in their middle ages and beyond face unique weight loss challenges requiring strategic, tailored solutions. That is where Cenegenics comes in.

Cenegenics is an age management medicine clinic featuring 100% personalized programs to help patients lose weight and keep it off for good. The program takes an all-encompassing approach to wellness and, beyond weight loss, patients also experience boosted energy, improved cognition, and better sleep, among other health improvements. Here, we examine what the Cenegenics weight loss program entails, and why it works so well.

Cenegenics Patients – Weight Loss Success

Dr. Ledda and Dr. Chavez have achieved long term weight loss with the Cenegenics Program, physicians lose significant amount of fat with Cenegenics Elite Health Program

Popular Diets – Why They Are Flawed

Nutrition is a significant factor in long term weight loss, Supplementation for weight loss is sometimes essential even with a solid diet

While there is no shortage of weight loss methods popular today, many of them are flawed in a number of ways. At the most basic level, people often pursue dieting without first developing an understanding of the ways in which nutrition impacts overall health. Indeed, nutrition is inherently complex: phytonutrients produce specific yet significantly different effects in the body.

Age management physicians have an in-depth understanding of how phytonutrients impact the body, as well as how their intake can be manipulated for long-term success in spite of slowing metabolisms and other factors affecting older adults. Additionally, these specialists can pinpoint the flaws in previous attempts made to enact dietary changes, including the shortcomings of many popular diet plans.

For one, they often fail to address the precise nutritional and caloric needs of the participating individual. Without an in-depth assessment of one’s health, it is impossible to pinpoint one person’s dietary needs compared to the next. Moreover, many individuals are unaware of how phytonutrients impact weight loss and health in general.

Not all calories are created equal, and in order to succeed with sustainable weight loss, people need foundational knowledge of recommended intake of both key nutrients and portion sizes. They need a prescribed plan that eliminates guesswork and takes into consideration the importance of the right phytonutrient mix.

The Problem with Lose Weight “Fast” Solutions

Perhaps most importantly, diets tend to fail because they are viewed as a short-term solution to a problem. Thus, the ways in which we view diets is inherently flawed: dietary changes are often sought out as a quick fix to losing weight, so the eating habits prescribed by many diets naturally fail to hold long-term value.

According to UCLA research based on analyses of more than 30 long-term studies, the majority of people participating in diets lost five to ten percent of their body weight, only to regain it later. Moreover, one- to two-thirds of people regain more weight than they originally lost within four to five years of dieting.[3]

Long-term compliance and a caloric deficit are the two components every nutrition plan needs for success. The first component is the one with which many subjects struggle. Highly restrictive diets are generally unsustainable over the long-term. While there are many different approaches that can be used to achieve weight loss, including high-protein eating plans, the one that will have the best odds of success is the one that the subject can maintain over a long-term basis.

In other words, individuals seeking permanent weight loss must begin to rethink the role of food to make lasting changes. Making healthy choices to promote nourishment based on a person’s lifestyle and preferences is far more effective than the traditional approach to dieting, which is often based on eliminating entire food groups or other restrictions, which make it increasingly difficult to maintain long-term compliance.

How Cenegenics Is Different for Long Term Weight Loss

We established in the previous section that the majority of weight loss endeavors often result in failure – or worse, added weight gain. What makes Cenegenics different from the rest? According to a recent study, Cenegenics members record an average decrease of 30% in body fat percentage.

How, then, does the program ensure compliance and actually deliver on its promises? Unlike diets, which tend to focus on a single facet of life (changes to eating patterns), the Cenegenics program takes a comprehensive approach to weight loss to achieve lasting lifestyle improvements. Specifically, the robust program encompasses the following key elements:

Cenegenics physicians specialize in long term weight loss

Expert Age Management Doctors

As mentioned above, nutrition can be a complex and challenging feat – but only if you lack the proper guidance. Cenegenics physicians are specifically trained and certified in age management medicine. They complete specialized training outside of their mandatory schooling and are therefore armed with the competency to administer exceptional care in all realms of age management, including nutrition and hormone regulation.

Unlike other wellness coaches or nutritionists, Cenegenics physicians do not simply prescribe plans and leave patients to their own devices. They monitor your program medically, based on follow-up lab results and phone conversations. Whether by phone, email, or in person, you can always contact your physician to discuss what is working or what may need to be refined based on lifestyle changes.

The Cenegenics team knows that sustainable weight loss is not a “one and done” activity; but instead, it must be continuously revisited to meet the evolving needs of the patient. This level of support cannot be found anywhere else, which is one of the primary reasons why Cenegenics is so vastly different from any other weight loss program.

How to Start with Cenegenics Weight Loss – The Cenegenics Elite Health Evaluation

The Cenegenics program begins with an Elite Health Evaluation to determine your metabolism, endocrine functionality, and overall physiology – all of which contribute to the ways in which your body processes nutrients. Based on these findings, Cenegenics physicians take corrective actions to help your body process at its highest possible level.

Your doctor will prescribe a low-glycemic food plan to eliminate or significantly reduce factors leading to increased inflammation, harmful insulin responses, fat production, and other negative impacts on health. Unlike fad diets, Cenegenics food plans are based on scientifically proven results. Not only do the plans promote sustained weight loss and management, but they also minimize the risk of developing serious conditions including cardiovascular disease, Type 2 diabetes, and hypertension.

Hormone Imbalances – Why They Matter for Weight Loss

Another reason traditional dieting falls short is because it overlooks possible hormone imbalances. Hormones, including those that influence metabolism such as cortisol, human growth hormone (hGH), and thyroid hormone, decline with age. Additionally, hormones such as testosterone impact muscle tone and development, while estrogen can affect digestion. Thus, hormones contribute to weight management in diverse and complex ways.

Following the Elite Health Evaluation, Cenegenics physicians make recommendations based on detected hormone levels. If clinically indicated, hormonal optimization may be encompassed by your treatment to achieve a balanced endocrine system to support a strong foundation for weight loss.

Personalized Cenegenics Exercise Plans for Weight Loss

Man high-fiving coach as he works toward his long term weight loss, Cenegenics customizes exercise and nutrition plans as a part of the Elite Health Program

One fallacy permeating today’s perception of weight loss is that one can simply exercise their way to a healthy body composition. Again, in order to achieve sustainable weight loss, a caloric deficit is essential. It is far easier to control calorie intake than it is to “out-exercise” poor dietary choices.

Nonetheless, exercise is essential to lasting wellness and permanent weight loss, and it can indeed spur further weight loss in individuals who are already making the right eating choices. Using exercise in combination with certain dietary choices – increasing protein intake, for instance – can have beneficial impacts in people seeking sustained weight loss.

Regular exercise can increase metabolic rates and improve body composition. Moreover, it can also lower heart disease risk. In fact, poor fitness levels are the deadliest risk factor for death among all – including hypertension, diabetes, obesity, heart arrhythmia, high cholesterol, and even smoking.

To support boosted efforts to achieve and maintain a healthy weight, along with a broad range of additional wellness outcomes, the Cenegenics age management program pairs patients with an appointed exercise physiologist to develop a plan fitting their personal lifestyle and health goals. They will balance exercises across three main categories: flexibility, cardiovascular fitness, and resistance/weight training.

Cenegenics Supplements for Weight Loss

Supplements for weight loss are available on the Cenegenics program and our online store

In addition to the phytonutrients we obtain through food sources, there are many additional vitamins, minerals, and antioxidants the body needs to support essential functions, including weight management. Some vitamins may even aid directly in weight loss.

For example, in a weight loss study of postmenopausal women, participants who achieved healthy or replete levels of vitamin D lost more weight than those who did not reach the same levels.[4] It is suspected that more than 40% of the U.S. population is deficient in this critical nutrient alone, which is precisely why Cenegenics physicians perform comprehensive blood work to determine individual deficiencies upon which supplement recommendations are made.[5]

To support better overall wellness, Cenegenics physicians prescribe a personalized regimen of nutraceutical supplements. As Cenegenics supplements are distributed for clinical use, manufacturing and quality assurance testing is held to higher regulation, surpassing the common standards observed in the retail supplement industry.

From raw material acquisition and manufacturing, to capsulation, bottling, and labeling, our facilities and team undergo multiple quality assurance checkpoints during the product development process. Prior to releasing finished nutraceutical products to our physicians and teams, Cenegenics testing confirms the final product meets label claims and passes United States Pharmacopeia testing for biomicroorganisms and heavy metals.

All aspects of manufacturing and product development are completed in our FDA-registered, NSF/NSF for Sports-certified facilities that are also awarded with the international Therapeutic Goods Association certification.

How It Works: The Science Behind Cenegenics’ Weight Loss Program

The previous section provided a comprehensive overview of the pillars behind Cenegenics’ powerful weight loss program. Here, we will dive deeper into the precise science of how Cenegenics helps patients achieve their weight loss goals.

Cenegenics Blood Analysis for Weight Loss

The highly comprehensive blood testing performed during the first phase of the Cenegenics Elite Health Evaluation yields invaluable insights. It is also performed frequently to measure compliance and program effectiveness. Below are the key insights pertaining to weight loss revealed in the patient’s blood work.

Insulin Sensitivity for Dietary Recommendations

One factor blood work determines is the patient’s insulin sensitivity, including fasting glucose, fasting insulin, hemoglobin A1c levels, and more. These findings will shape the precise dietary recommendations set forth in the patient’s food plan.

Reductions in insulin levels allow fat to be selected as the preferred fuel for the body’s energy supply, and the most direct way to achieve this is through carbohydrate restriction. The patient’s insulin sensitivity will therefore determine carbohydrate selection. For instance, some patients may need to limit carbohydrate intake to only vegetables, while others may benefit from a mix of vegetables, fruit, sweet potatoes, and/or whole grains.

Cholesterol Levels Reveal Lipid Metabolism

A patient’s blood analysis also reveals their lipid metabolism, or their body’s ability to break down or store fats for energy. Cholesterol levels, including high-density lipoprotein (HDL, or the “good” cholesterol), low-density lipoprotein (LDL, or the “bad” cholesterol), triglycerides, and coronary risk ratios are measured.

These findings will aid in fat selection for the individual and will confirm whether high-intensity exercise is being performed as directed throughout the course of the program. High-intensity interval training (HIIT) increases fat burning due to higher exercise intensity and long-lasting excess post-exercise oxygen consumption (EPOC).

Additionally, blood work results will help physicians provide recommendations for fat intake. Like other phytonutrients, there are different types of fats, some of which have better health properties than others. Another common misconception is that fat intake is directly linked to weight gain.

In reality, excess carbohydrate consumption is the main culprit behind obesity. This falsehood is, in part, why low-fat diets tend to produce poor results. Cenegenics physicians support patients in incorporating healthy fats from whole food sources into their diets, including nuts, avocados, and oils.

Inflammatory Markers Can Indicate Risk for Cardiovascular Disease

Inflammatory markers are strong risk indicators for cardiovascular disease.[6] Blood tests may measure C-reactive protein, among others. These will confirm whether sufficient compliance with food and exercise plans is being achieved or if there are any new issues requiring attention.

Body Composition Assessment – Measuring Body Fat%, Muscle Mass and Bone Density

Cenegenics physicians perform a complete body composition assessment via dual-energy x-ray absorptiometry (DXA) scan, the most trusted method for determining body fat and lean mass. The testing can determine trunk body fat, android body fat, and visceral fat, providing a far more comprehensive picture of body composition than other methods.

While body mass index (BMI) was once the leading measure of being overweight, its calculations can be misleading. It takes into consideration only height and weight, thereby failing to account for how body composition breaks down into fat, bone, and lean tissue.

They can also determine measures of visceral adipose tissue (VAT), or the body fat, which, in excess, is linked to cardiovascular disease and osteoporosis. DXA scans thus provide a far more accurate measurement of specific types of fat content, helping physicians provide targeted recommendations for diet and exercise. With routine scanning, they can track trends to see if nutrition and exercise programs are achieving correct intensity and frequency levels needed to push changes in biometrics.

Measuring Oxygen Consumed for Weight Loss

Man taking VO2 Max Test to help optimize long term weight loss, Understanding your fitness level helps Cenegenics physicians plan for long term weight loss

As part of the age management evaluation, Cenegenics physicians perform a cycle test using the sophisticated VO2 max to evaluate oxygen consumption. VO2 max measures the cardiac output and volume of oxygen consumed and is dependent on sex, age, and weight. Oftentimes, body fat loss leads to improved VO2 max.

The findings revealed through routine VO2 max testing will confirm whether sufficient compliance is achieved to improve cardiovascular and pulmonary fitness to reduce risk of all-cause mortality. In addition, the results offer insights to ensure exercise intensity is prescribed correctly for each individual.

Ongoing Clinical Support for Weight Loss

Finally, Cenegenics patients will receive ongoing support from their physicians through every step of their wellness journey. This team of specialists routinely ensures their patients have the tools, resources, and information needed to maintain better health for life. They also reinforce lifestyle changes – instead of simply prescribing them – to build accountability, thereby facilitating lasting results.

Is Cenegenics the Right Fit for Your Long Term Weight Loss Goals?

Man cheering having achieved long term weight loss goals

It is never too early – nor too late – to pursue a weight loss journey with age management specialists. Cenegenics physicians provide evidence-based exercise and diet prescriptions based on your body’s unique needs and lifestyle factors to support lasting weight loss and better overall health. If you have been frustrated by ineffective diets and exercise plans in the past, do not hesitate to contact your nearest Cenegenics location to finally get the results you have always wanted.

Get Started Now on Your Weight Loss Journey

Key Resources

This guide was produced with contributions from the following key resources: 

Textbook of Age Management Medicine Volume 1

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook of Age Management Medicine Volume 2

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] “Obesity and Overweight. Centers for Disease Control and Prevention. 13 June 2016. Retrieved from URL: https://www.cdc.gov/nchs/fastats/obesity-overweight.htm

[2] “Health Risks of Being Overweight.” National Institutes of Health. Feb. 2015. Retrieved from URL: https://www.niddk.nih.gov/health-information/weight-management/health-risks-overweight

[3] Wolpert, Stuart. “Dieting does not work, UCLA researchers report.” UCLA Newsroom. 03 Apr. 2007. Retrieved from URL: http://newsroom.ucla.edu/releases/Dieting-Does-Not-Work-UCLA-Researchers-7832

[4] Mason et al. “Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial.” The American Journal of Clinical Nutrition. 1 May 2014. Retrieved from URL: https://academic.oup.com/ajcn/article/99/5/1015/4577359

[5] Forrest, KY and Stuhldreher, WL. “Prevalence and correlates of vitamin D deficiency in US adults.” Nutritional Research. Jan. 2011. Retrieved from URL: https://www.ncbi.nlm.nih.gov/pubmed/21310306

[6] Kritchevsky et al. “Inflammatory markers and cardiovascular health in older adults.” Cardiovascular Research.

Couple sailing with improved energy from Cenegenics Age Management Medicine, Couple combating challenges of aging with the help of age management doctors and preventive care

Understanding Preventive Care: Age Management vs Anti-Aging

It seems that aging has had a negative connotation since the beginning of time. In fact, the first anti-aging treatments are believed to have originated as early as 69 BCE.[1]

It’s therefore no surprise that the “anti-aging” market has sustained such immense levels of success.

By definition, the term “anti-aging” describes a product or technique designed to prevent the appearance of growing older. Indeed, our fascination with preserving a youthful appearance spans far and wide and is documented through thousands of years’ worth of texts.

While the proverbial “fountain of youth” may be something of lore, it is apparent by today’s abundance of age-fighting products and plethora of surgical procedures that the quest for youth has stood the test of time. Although there is no question that preserving a vibrant, youthful appearance is coveted as an ideal across virtually all societies, the question remains: Is aging really only skin deep? And, if not, is the anti-aging market missing the mark?

The Difference Between Age Management Doctors and Anti-Aging Doctors

By definition, anti-aging prevents the appearance of aging but age management medicine combats the common challenges of aging including decreased energy, cognition, sleep, libido and inability to manage a healthy weight.

age management doctors focus on exercise and nutrition to assist in combatting the symptoms of aging

How do I look younger? Apparently, this is the $250 billion question. This figure represents the estimated worth of the Global Anti-Aging Market in 2016, which is projected to grow at a CAGR of 5.8%, with a forecasted value of $331.41 billion by 2021.[2]

The anti-aging market encompasses a broad range of products, treatments, services, and devices, with everything from liposuction services to remove belly fat to microdermabrasion devices for resurfacing skin. The many products and practices that fall under the umbrella of anti-aging, as well as the concerns they target, continue to remain at the forefront of middle-aged individuals’ minds.

Yet, we must ask ourselves this: If we’re spending $250 billion on anti-aging treatments worldwide, shouldn’t we be more satisfied with the results? Shouldn’t the way we look be a direct result of also feeling our best? Perhaps age management should not start on the outside, but rather, should be approached from the inside out.

Age Management: A Better Approach

First and foremost, it’s important to debunk the notion that any treatment, procedure, or product has “anti-aging” powers. Age is an inevitable fact of life; each person has been doing it since they reached maturity. In fact, in the Textbook of Age Management: Volume 1, authors Jeffrey P. Leake, MD and Todd D. Greenberg, MD confirm that aging actually begins by the age of 25.

Thus, there is no such thing as anti-aging. This does not mean, however, that we must accept many of the factors that come with age: feeling always tired, struggling to maintain a healthy weight, lacking energy for exercise, fighting hormone imbalances, or living in persistent discomfort. This is precisely where age management – a more realistic and effective approach to overcoming the challenges of aging – comes in.

A Closer Look at Aging

Physicians reviewing differences between anti-aging treatments and age management, Age management doctors approach to aging is far superior in comparison to anti aging doctors

Many of us have used a number of anti-aging treatments. At the very least, the majority of us are aware of their potential outcomes. Yet, how well do we understand what it is we’re really trying to fight? Aging is not just a single process, though it is often summed up as just “getting older.” There are far more intricacies than two words alone can capture. What actually occurs to our bodies as we age?

In 1991, aging was defined by the book Evolutionary Biology of Aging as a “persistent decline in the age-specific fitness components of an organism due to internal physiological deterioration.”[3] In the field of developmental biology, aging is suggested to be defined as the time-related deterioration of the physical functions necessary for survival. These characteristics of aging, along with diseases of aging (heart disease, metabolic disorders, etc.) affect all the individuals of a species.

Interestingly, of all the products, services, and devices mentioned in the Global Anti-Aging Market Research Report & Forecast, not one emphasizes improving cellular function and optimizing health to manage physiological deterioration. That’s because anti-aging services target only the visible effects of aging, without targeting their underlying causes – and therefore completely overlooking wellness as a whole.

Age Management – Based on Medical Science

Cenegenics provides preventive care from certified age management doctors focused on helping you optimize your health, anti aging doctors focus on how you look vs combatting the symptoms of aging

Upon reaching physical maturity, the aging process begins in both men and women, but the process of aging typically goes on without notice throughout the twenties and thirties. More measurable changes are commonly observed by middle-age and later. For women, a significant process of aging – menopause – occurs relatively abruptly in comparison to a man’s transition from their ability to reproduce or not.

In either case, by the time men and women are middle-aged, significant biomarkers of aging are commonly affected, ranging from hormone production to the ability to deliver oxygenated blood to muscle tissue. For those whose aim it is to manage these significant components of the aging process, the rewards extend far beyond the image of youthfulness alone.

In the past, health was recognized by the absence of disease. Now, however, the World Health Organization encourages us to take our approach to health further than disease prevention alone, stating that it is “a state of complete physical, mental, and social well-being.”[4] Yet, despite the evolution of this definition throughout the last century, the model of traditional medicine is still a reactive one.

In other words, most of us do not seek medical expertise until an apparent health issue has manifested. Likewise, significant medical attention is not prioritized until individual biomarkers are out of clinical ranges, by which point intervention – either invasive or noninvasive – is introduced.

Age Management - How Physicians Take a Superior Approach

Improved neurocognitive function and cardiovascular performance are some of the benefits you can expect from age management medicine, anti-aging doctors focus on improving the appearance of age

Age Management Medicine is a proactive – versus reactive – approach to optimizing health and quality of life. It is achieved by continuously measuring comprehensive biomarkers of aging.

Biomarkers of aging can measure everything from cognitive function to physical strength, as well a person’s genetic makeup. These factors provide physicians with the most comprehensive overview of an individual’s wellness as possible, thereby giving them predictive insights which can be used to develop a targeted age management plan.

For instance, by collecting extensive diagnostic information and learning about a patient’s detailed lifestyle and medical history, age management physicians and clinical teams are able to develop customized nutrition, supplementation, exercise, and bioidentical hormone programs – taking a holistic approach for each individual patient.

Age Management: The Power of Preventive Care

Man cheering having achieved long term weight loss goals

Not only is the age management approach highly personalized according to the individual’s distinct needs, but it also surpasses traditional methods in the fact that it is preventive. The field of medicine has only just recently begun to unlock the power of preventive care. In 1995, for instance, medical experts speculated that “national attempts to change lifestyle and alter cardiovascular risk factors… will not achieve health gain.”[7]

Fast-forward 30 years: there are now countless initiatives in place supporting the exact opposite belief. Most notably, the Office of Disease Prevention and Health Promotion is nearly a decade into its Healthy People 2020 program, which was launched in 2010. With more than 1,200 objectives across 42 topic areas, one of its critical pillars is to “attain high-quality, longer lives free of preventable disease, disability, injury, and premature death.”[8]

With events like the Healthy Aging Summit and a specific objective of increasing the proportion of adults who are up-to-date on clinical preventive care services,[9] it’s clear that this – and many other programs – are in steadfast support of taking a risk-based, preventive approach to age management, versus a reactive one.

Challenges with Proactive, Preventive Medicine

Indeed, experts are waking up to the immense potential of proactive healthcare. In 2014, Forbes published an article titled “The Huge, Neglected Opportunity for Proactive Medicine.”[10] It draws attention to the fact that the U.S. healthcare system spends the majority of its resources – a whopping 80% – caring for the seriously ill. Proactive medicine, the author posits, is more challenging because it requires “really getting to know people and working with them over time to change their lives.”

Yet, focusing mainly on caring for diseases after they’ve been diagnosed versus preventing them proactively via preventive care only allows the vicious cycle to continue. Isn’t the preemptive quest for long-term health a better approach to take? That’s what age management doctors believe, which is why they help their patients improve across a broad range of wellness outcomes.

Age Management Doctors – What Do They Do?

Cenegenics physicians specialize in long term weight loss

Age management doctors don’t simply treat the signs of aging which have already manifested (although they are experts in that area as well). Beyond addressing issues like lack of energy, hormone imbalances, struggles with weight loss programs, aging clinics also help individuals improve future health outcomes.

By understanding how bodily changes influence each patient’s health, age management clinical teams can provide better personalized care, focusing on the key factors that require the most attention first. This concentrated and continual effort brings significant value to a growing field of prevention-based medicine, as each individual’s risk factors are managed within optimal ranges over decades, thereby significantly lowering the risk of disease development.

Healthy Aging - A Step-by-Step Approach

First, age management physicians perform an all-encompassing individual assessment to form a detailed overview of current wellness levels and health history. Based on their findings, they generate a treatment plan encompassing to address the following five pillars of health.

Increased Energy Levels

Low energy levels are common in older adults. By the time people reach the age of 70, roughly 30% of the muscle mass they had at the age of 20 is gone.[11] This often results in decreased strength, increased fatigue, and overall lower energy levels.

Yet, some causes of decreased energy cannot be attributed to age alone. From anemia to chronic disorders, there could be an underlying cause for persistent tiredness. Oftentimes, however, because exhaustion is typically perceived to some degree as a normal part of aging, it is not enough in itself to prompt older adults to see their physician.

For people who are always tired, however, the fix could be as simple as adopting a new supplement regimen. This is one of the key areas in which age management doctors specialize: determining whether lifestyle changes alone are enough to address declining energy levels associated with aging, or whether a more aggressive approach is needed to target an underlying cause of the symptom.

Improved Sleep

Disordered sleep is certainly not exclusive to older adults. In fact, it is of chief importance throughout a person’s youth, because ample, quality rest supports healthy childhood and adolescent development. Yet, while sleep is also critical to wellness in older adults, its importance is often overlooked. In fact, the consequences of untreated sleep disorders can take a physical and mental toll on this age group, contributing to functional limitations and a higher risk of death from any cause.[12]

Inability to fall and stay asleep is fairly common: 38% of Americans report feeling poorly rested four or more days each week, and just over half (54%) are able to clock in the recommended seven to eight hours of sleep every night.[13] Yet, just because an issue is common does not mean it should be ignored. Sometimes, individuals fall under the false assumption that common is synonymous with normal, and therefore neglect to seek medical help.

Both lack of sleep and poor sleep quality put an individual at risk for a broad range of short- and long-term health issues. On a short-term basis, sleep is needed for immune system functionality, metabolic function, and safety while completing daily tasks. Over the long-term, untreated sleep disorders are associated with increased risks of:

Specifically, there is a proven interplay between sleep and inflammation – particularly in the cardiovascular system. The Textbook of Age Management Medicine: Volume 1, describes this relationship as follows: “Sleep duration is inversely associated with plaque formation and coronary artery calcification among middle-aged adults, and is inversely associated with carotid intima media thickness.”

Indeed, several pro-inflammatory markers are inversely associated with sleep duration, which confirms the fact that sleep deprivation is linked to morbidity and mortality, as well as increased cardiovascular disease.

Obstructive Sleep Apnea

There are many barriers to a good night’s sleep, with sleep-disordered breathing (SDB) being a main cause in older adults. The Textbook of Age Management Medicine: Volume 1 explains that obstructive sleep apnea (OSA) in particular is an epidemic affecting up to 24% of the population, though the actual volume of cases could be even higher as many patients are undiagnosed.

OSA is a condition that largely affects obese individuals, but it can also afflict others. It is characterized by insufficient airflow, for which both noninvasive treatments such as weight loss, as well as surgery, may be recommended.

No matter the speculated cause, a physician must assess each individual’s sleep-related issues to determine the best means of treatment. By addressing the sleep disorders themselves, instead of the byproducts they create, age management physicians can help patients improve both long- and short-term health.

Mental Acuity - Enhanced Cognitive Function

The mind is something that changes with age. Yet, neural and cognitive functions are complex, and age-related changes in brain structure and function are not uniform across the population. Promoting cognitive function in middle-aged and older individuals is therefore an endeavor that requires an individualistic approach.

In Brain Aging: Models, Methods, and Mechanisms, author Elizabeth L. Glisky writes that “the basic cognitive functions most affected by age are attention and memory.”[14] Yet, age alone is not the only factor which plays a role in the performance of these cognitive functions. As the Textbook of Age Management Medicine: Volume 1 explains, exercise, alcohol consumption, sleep, diet, and even caffeine intake can all contribute to brain health.

Determining the many ways in which these factors affect the mind as we age requires an extensive look into an individual’s current measures of health, medical history, and lifestyle. Through approaches such as nutraceuticals (natural compounds reported to enhance natural functions), and prescriptive lifestyle adjustments, physicians can advise a tailored preventive care treatment plan to help patients minimize the impact of age-related cognitive decline.

Weight Loss - Effective Weight Management

There is a general perception that few individuals ever succeed with long-term weight loss. Because metabolic rate declines by 2% or more per decade after the age of 25,[15] it is also a widely held belief that weight loss becomes more challenging with age.

Yet, factors like age, and even exercise, are less important than the volume and types of food we eat. In fact, the Textbook of Age Management Medicine: Volume 1 explains that the belief that obesity is caused by a contemporary sedentary lifestyle and lack of exercise is a myth. Rather, obesity is a result of eating too much.

The text also reveals a silver lining: obesity is the most preventable disease in the U.S. The question remains, then: What is the best way to lose weight? If the volume and types of food being consumed are contributing to obesity, which is directly linked to morbidity in the form of heart disease, cancer, diabetes, and high blood pressure,[16] why do so many people continue to struggle with an eating plan that supports weight management? The CDC confirms that more than a third of all U.S. adults are obese, with the highest concentration of obese individuals falling within the middle age range (40.2%).[17]

The Textbook of Age Management Medicine: Volume 1 sheds some light on this issue:

Weight Loss - Eating What You Need

We tend to maintain the same weight over time. We do so by eating similar weight and/or volumes of food each week. However, because of processed foods, which are abnormally dense in energy, that similar weight and volume of food results in a constant insult to the body (inflammation and insulin surges).

While scientists are continuing to refine their understanding of how the human body interacts with our environment, we are still a long way from manufacturing the nutritional value of natural food. Thus, consuming whole foods (versus processed foods) is the best way to achieve sustainable weight loss.

Yet, this is complicated by the fact that a calorie is not just a calorie. Following a well-rounded diet geared toward weight management requires a precise balance of macronutrient intake, including being mindful of carbohydrate and protein levels in foods consumed. We must eat what we need, not what we want, which requires commitment to an active process that is achieved most effectively when overseen by nutritional experts.

Weight Loss - Quick Solutions?

Weight loss is one area in which age management and age-fighting approaches may vary most drastically. The age-fighting industry tends to prioritize “quick fixes” and those which yield the most noticeable cosmetic results.

Liposuction services, abdominoplasty, and anti-cellulite treatment devices are marketed as effective means of improving appearances for overweight individuals. Even bariatric surgery is sometimes positioned as a quick fix to obesity, allowing severely overweight individuals to shed pounds by surgically enforcing restrictive eating habits.

What’s important to remember is this: there is no way to achieve sustainable weight loss without maintaining a healthy diet. Even solutions which may reduce fat quickly will not have lasting results without long-term commitment to eat well on the patient’s part. More importantly, these quick fixes do not carry the same far-reaching health benefits of a nutritional eating plan to achieve an improved clinical state.

What About Exercise?

If nutrition is the single most important factor in maintaining a healthy weight, is it even worthwhile to pursue regular physical activity? The answer is a resounding yes. As the Textbook of Age Management Medicine: Volume 1 confirms, “Exercise is perhaps the least used but most effective and most thoroughly studied therapy we have against chronic disease and ailments of age.” It protects against decline in the physical, sexual, and emotional domains, and is especially powerful in reducing inflammation.

Yet, this still leaves many adults wondering: What types of exercise are best? How much exercise should I be getting each week? Or, for that matter, each day? Is high-intensity interval training (HIIT) more beneficial than moderate-intensity exercise? These answers will vary significantly based on each individual’s specific goals; strength, endurance, and flexibility levels; current health measures; and even their genetic markers. This is just yet another example of an instance in which a physician-led, comprehensive approach to age management is ideal.

Increase Libido

Couple toasting champagne to increase intimacy after increasing their libido with Cenegenics Age Management program, anti-aging treatments do not help increase libido

A declining libido isn’t something that occurs overnight. Loss of sexual desire is impacted by physical and mental health factors, along with age. While it is something that is seldom discussed openly, declining sex drive can take its toll on an individual’s overall wellbeing, as well as the quality of a relationship.

Research shows that loss of libido impacts women more than men, with 34% of females and 15% of males reporting a noticeable decline in their sex drive.[18] The challenge in addressing low sexual interest lies in the fact that the condition can stem from a host of contributing factors. Fatigue, poor mental health, and even relationship factors can affect sex drive for both men and women.

Additionally, the body experiences immense hormonal changes with age. The Textbook of Age Management Medicine: Volume 2 explains that in men, for instance, dwindling testosterone can have a negative impact on the physical, sexual, and emotional domains of wellness. Women, too, can face health risks when they become hormone deficient.

Like weight management, exercise, and sleep, addressing variances in sex drive necessitates a patient-centric approach. It requires physicians to perform a comprehensive analysis into overall physical and mental health to determine the best course of action.

Age Management - The Far-Reaching Power

Cenegenics helps couple increase muscle mass and lose weight, anti-aging treatments focus on the appearance of aging but cannot help with weight loss

By this point, it’s clear that the undeniable, far-reaching impact of age management clearly overpowers the isolated results anti-aging solutions aim to achieve. The anti-aging industry addresses common pain points shared among many middle-aged and older adults, offering services such as hair restoration, eyelid procedures, and weight loss surgeries, as well as anti-wrinkle products and laser devices.

All of these costly treatment options only address issues that are skin-deep, and therefore fail to make any impact on the true underlying agents that actually contribute to these symptoms of aging.

Age management, on the other hand, takes a more powerful and all-encompassing approach to wellness and aging. By addressing all of the internal and external factors that can compromise wellness as we age, physicians specializing in age management effectively tackle health challenges from the inside out. Increased energy levels, weight management, better sleep, improved cognitive function, and stabilized libido are the end result, with a more vibrant, lean, and youthful appearance simply being an added benefit.

Cenegenics - An Individualized Approach to Preventive Medicine

Age management solutions are not exactly simple, however. Because each individual has a complex set of genetic, environmental, and lifestyle factors to consider, the approach must be tailored precisely to a person’s unique needs.

From exercise recommendations to nutrition plans, hormone replacement therapy to a regimen of nutraceuticals, there are many ways age management physicians can derive tailored treatment plans targeting specific wellness outcomes. While pinpointing a person’s exact needs and establishing an individualized age management plan may require a small investment of time up front, the lasting benefits are well worth the effort.

The growing field of age management differs from anti-aging in many ways, but the most obvious is in the name. The aging process cannot be stopped, but one can effectively manage the progression of age-related decline.

Preventive Medicine - More than a Routine Checkup

Through tactics such as frequent blood analysis, food and nutrient testing, exercise analysis, body composition assessments, and other types of biometric data collection, age management physicians can not only track how food, exercise, and sleep influence a patient’s health, but also how properly managing hormone levels can reduce risk factors associated with serious conditions like heart disease and metabolic syndrome.

Ultimately, the consumers of anti-aging solutions want to live vibrant, healthy lives until their final day, but are most attracted to the perception of health. The outcome of age management and anti-aging solutions may not seem very different but, for the latter, the course of action is almost always short-sighted.

As the field of age management continues to develop, a growing number of consumers are beginning to educate themselves and are subsequently taking the more effective and comprehensive approach to address aging. Now, you can consider yourself among the well-informed individuals who know that wellness and youthful energy lies far deeper than the skin’s surface, and that the biomarkers of aging hold the true power to measuring and promoting long-term wellness.

Next Steps in Understanding Preventive Care & Age Management

FREE Consultation

Our world class physicians create a personalized plan to help you feel 10+ years younger. You'll be more energetic, lose weight, sleep better, have more libido, and think more clearly. Click below to schedule a free consultation with one of our physicians. It's quick + easy. 

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.


[1] Morrill, Hannah. “Charting: A Brief History of Anti-Aging.” Harper’s BAZAAR. 2016.

[2] Global Anti-Aging Market Research Report and Forecast to 2017-2022; OrbisResearch.com.

[3] Rose, Michael R. Evolutionary Biology of Aging. Oxford University Press, 1994.

[4] World Health Organization, 2018. Retrieved from URL: http://www.who.int/suggestions/faq/en/

[5] American Federation for Aging Research, 2018. Retrieved from URL: https://www.afar.org/infoaging/biology-of-aging/biomarkers-of-aging/

[6] Biomarkers of Aging. American Federation for Aging Research, 2016.

[7] Gillies et al. “Balancing proactive and reactive care.” Occasional paper series, Royal College of General Practitioners, 1995.

[8] “Healthy People 2020.” National Centers for Health Statistics, Centers for Disease Control and Prevention, 2015. Retrieved from URL: https://www.cdc.gov/nchs/healthy_people/hp2020.htm

[9] “Older Adults.” Healthy People 2020. Retrieved from URL: https://www.healthypeople.gov/2020/topics-objectives/topic/older-adults/objectives

[10] Hixon, Todd. “The Huge, Neglected Opportunity for Proactive Medicine.” Forbes. 19 Aug. 2014.

[11] Dennis, Helen. “Successful Aging: Causes of energy loss in older adults.” Los Angeles Daily News. 29 June 2015.

[12] Paudel et al. “Rest/Activity Rhythms and Mortality Rates in Older Men: MrOS Sleep Study.” Chronobiology International. 06 Apr. 2010.

[13] Sleep and tiredness survey. YouGov. 02 June 2015. https://today.yougov.com/topics/lifestyle/articles-reports/2015/06/02/sleep-and-dreams

[14] Glisky, Elizabeth L. Brain Aging: Models, Methods, and Mechanisms. CRC Press. 2007.

[15] Boston, Gabriella. “Basal metabolic rate changes as you age.” Washington Post. 05 March 2013.

[16] Stanford Health Care. Retrieved from URL: https://stanfordhealthcare.org/medical-conditions/healthy-living/obesity.html

[17] “Adult Obesity Facts.” CDC. 29 Aug. 2017. https://www.cdc.gov/obesity/data/adult.html

[18] Graham et al. “What factors are associated with reporting lacking interest in sex and how do these vary by gender?” BMJ Open. 2017.

What is Genetic Testing?, Cenegenics genetic testing analyzes all twenty two thousand of a patient’s genes, Cenegenics entered exclusive partnership with New Amsterdam Genomics to offer state-of-the-art genetic analysis to provide instrumental genomic data to your Cenegenics physician to improve your program

What is Genetic Testing? Advanced Genomic Analysis with Cenegenics

Cenegenics Genetic Testing – Programs Tailored to Your Genetic Composition

Unlike others in their field, NAG analyzes all 22,000 of a patient’s genes, not only digitally, but also through the eyes of physicians to ensure outcomes are exact. Additionally, the company works with top research professionals from Harvard and Stanford to obtain and utilize the most up-to-date genetic information available.

Cenegenics Elite Heath is the largest and most experienced Age Management Practice in the world, focusing on nutrition, exercise and bio-identical hormone optimization. Through their exclusive partnership, Cenegenics is able to offer NAG’s personalized genetic testing to each member of its diverse and extensive patient base.

This will be life changing for Cenegenics’ patients who will now have health and pharmaceutical recommendations tailored specifically to their genetic composition. Cenegenics physicians are in the best position to contextualize this genetic information and drive action in order to mitigate potential health risks, helping their patients achieve a more proactive and preventive lifestyle.

“Cenegenics is thrilled to begin this relationship with New Amsterdam Genomics,” said Partner at Cenegenics Denver, Julie McCallen, MD. “We are completely focused on helping our patients live the longest, healthiest, and happiest lives possible, and I believe through this partnership we can work even more thoroughly towards achieving this goal.”

Meet Your Cenegenics Genetic Testing Team

The agreement secures for New Amsterdam Genomics the distinction of becoming the exclusive genetic testing option for all Cenegenics Elite Health Program members worldwide. Through Cenegenics, members will be able to get their entire exome sequenced by NAG’s CLIA-certified clinical laboratory and advanced algorithms.

These members will also have access to NAG’s secure online portal that provides them, as well as their Cenegenics physician, with medical insights based on their molecular traits. With the patient’s genome decoded, the physician and the patient can devise ways to optimize the patient’s health. Furthermore, the patient and physician will have lifetime access to the patient portal, allowing continuous updates on the patient’s genetic analysis as new genetic studies are published.

“We’re extremely honored to begin this important work with Cenegenics physicians and their patients,” said Andrew Mills, PhD, New Amsterdam Genomics CEO and Founder. “We are certain this kind of genetic testing will lead to longer, heathier lives.”

Adam Christopher Troeder, NAG’s VP and Founder of the Genomic Alliance stated, “For us, this is about giving as many people as possible an opportunity to improve quality of care and clinical outcomes, while also lowering healthcare costs and providing a more preventive approach healthcare.” Adam also added, “It will be an absolute pleasure working with Dr. Julie McCallen and the Cenegenics team on this roll out and future iterations of the product. Over time, we will become even more customized for Cenegenics patients, as the Cenegenics team sees fit.”

About Cenegenics

Founded in 1997, Cenegenics is proud to be the global leader and recognized leading authority in Age Management Medicine with over 35,000 patients worldwide. Cenegenics’ cofounders and visionaries, Alan Mintz, MD and John E. Adams, CEO, pioneered the field of Age Management Medicine, establishing a vital and much needed role in the international medical community.

Cenegenics bridged the gap between conventional medicine and a science-based, proactive approach to decrease the risk of age-related disease and lengthen health-span.

About New Amsterdam Genomics

New Amsterdam Genomics (NAG) was started in 2010 by Andrew Mills and is headquartered in Manhattan, New York. From disease prevention, risk assessment, and patient education, to cancer research and treatment, genomics stands to make healthcare a completely personalized experience.

NAG wants to empower each patient and their physician with the power of genomic data, and has lead the charge by developing a genomic analysis platform and suite of computational algorithms that determine the impact a person’s genome has on their health and wellbeing, all delivered through a point-of-care tool designed for clinical use and looking to optimize the patient experience and understanding of their DNA.

About the Genomic Alliance

The Genomic Alliance was founded in 2013 by Adam Christopher, and is a national consortium of medical professionals focusing on the exploration and development of Genetic Testing as it pertains to personalized care and best practices. The Genomic Alliance has taken the experience and perspective of thousands of medical professionals from all over the country in order to begin better understanding genetic testing best practices and utilization of genetic information to provide proactive and preventive care.

How Genetic Testing Can Improve Your Health – In Conclusion

Cenegenics partnered with New Amsterdam Genomics to create even more personalized programs for you through advanced DNA analysis. The results of your genetic test can help determine your risk of serious medical problems, assist in tailoring your diet, exercise and lifestyle choices to optimize your health, as well as determine which supplements will be most effective for you in order to reach your goals.

Next Steps to Schedule Your Health Evaluation with Cenegenics

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.

Age management medicine helps shift the paradigm from disease driven medicine to preventive healthcare, Cenegenics helps reduce risk of chronic disease with a comprehensive approach to medicine

What Is Age Management Medicine?

Age management medicine is not a new concept. An old Chinese proverb states:

“The inferior physician treats the disease once it occurs. The mediocre physician prevents the disease from coming back. The superior physician prevents the disease from ever occurring.”

Traditional thought has programmed us to expect aging and debilitating symptoms as an inevitable gloom, slowly penetrating our lives from middle age onward. That is not necessarily true. Research and time-tested therapies prove differently. Studies have redefined “healthy” as “living with the energy and vitality of someone years younger”. Achieving that level of health adds life to your years.

Age management medicine shifts the emphasis from disease-driven medicine to a preventive health medical practice, centered on evidence-based protocols that work synergistically to give you proactive, preventive healthcare.

In 1997, Cenegenics pioneered age management medicine and is both highly regarded in the medical community and the indisputable leader in this field. Cenegenics relies on the science of age management medicine to help identify and meet criteria, which places you in the lowest possible risk category for disease—particularly heart disease, cancer, stroke, diabetes, metabolic syndrome and Alzheimer’s Disease—and thereby extending your health span.

By incorporating hormone optimization (when clinically indicated) harmoniously with appropriate exercise, nutrition, and supplementation in customized programs, Cenegenics can help target your specific health goals and get you on track to a healthier you.

Why Cenegenics?

#1 Leader. Thanks to the focus on preventive care, over 35,000 men and women worldwide are living their lives to the fullest with Cenegenics.

Trusted. Physicians trust us, as their families represent 25% of the Cenegenics elite membership. Cenegenics is also affiliated with the nonprofit Cenegenics Education and Research Foundation which proudly offers physicians a CME-accredited educational course in age management medicine.

Expert science, expert staff. At Cenegenics, you can count on progressive, evidence-based solutions for your health, delivered by dedicated physicians who are specifically trained and certified in age management medicine.

What changes in your health can you expect?

Decreased body fat percentage – A recent study shows that our patients reduced their body fat index in their first year by an average of 30%*.

Increased muscle tone & strength – Your Cenegenics physician and clinical team of professionals will create a fully personalized exercise and nutrition plan to help you meet your physical goals.

Improved sexual drive & function – Based on the recommendation of your Cenegenics physician, nutritional supplements and prescription hormones (as clinically indicated) are prescribed to optimize hormonal function.

Managed stress levels & improved mental acuity – Each segment of your plan is a vital building block designed to support your goals for a heightened sense of well-being that comes from restoring your body’s balance.

Refreshed sleep & increased energy levels – Your personalized plan can result in restored energy, less daytime fatigue, and better quality sleep.

Next Steps

We hope the information above assisted you in your research process and below are  additional links which you might find helpful.

We offer a free consultation that can help further answer any questions you may have, please click here to register.

Additional Information

For additional information on What is Cenegenics? – Click Here

*Based on internal study of the last 200 Cenegenics patients completing their first annual re-evaluation, the average body fat percentage declined 30% from the initial extensive evaluation when joining the Cenegenics program. 


Cenegenics is the clinical leader in age management medicine and has treated over thirty five thousand patients, the elite health evaluation focuses on establishing your medical baselines which will help determine the foundation of your programming

Key to Health & Wellness: What is Cenegenics?

Founded in 1997, Cenegenics is the clinical leader in age management medicine having treated over 35,000 patients, 25% of which are physicians and their families. Cenegenics takes a comprehensive approach to preventive medicine enabling patients to achieve optimal health instead of the traditional approach of treating diseases as they arise. Based on an internal study, the average Cenegenics patient reduces their body fat index by 30% in the first year on the program.

Take Back Your Vitality with the Cenegenics Program

Each Cenegenics program is tailored to optimize your health & wellness by addressing issues such as weight management and important genetic markers

Cenegenics provides a partnership that supports a life-changing experience. We proudly offer you access to elite medical experts who remain by your side throughout your transformation. Whether you’re already healthy and looking to take yourself to the next level, or ready to make a change that will benefit you for the rest of your life, Cenegenics will tailor a program to ensure your lifelong goals are met and surpassed. Cenegenics cost is all-inclusive.

The Cenegenics Elite Health Evaluation

Man meeting with exercise physiologist during Cenegenics Health Evaluation, physician establishing baseline during Cenegenics evaluation

The foundation of the Cenegenics program is the Elite Health Evaluation. This full day of testing establishes your hormonal, physiologic and fitness baseline, serving as the basis of your Cenegenics program. The components of the evaluation include:

•  Medical history and lifestyle assessment

•  Comprehensive blood tests

•  Physical evaluation

•  DEXA scan - determines bone density

•  Body composition scan - measures total and regional body fat

•  CIMT (a specialized ultrasound of the carotid arteries) for heart attack and stroke risk assessment

•  Core strength and flexibility assessment

•  VO2 testing - determines your aerobic fitness level and heart rate training zones

•  Neurocognitive testing

•  Open-ended physician consultation

•  Presentation of your plan of action

A Lifetime of Ongoing Health & Wellness

People are often curious about What is Cenegenics?, Cenegenics is the clinical leader in age management medicine, Cenegenics helps shift the paradigm from the traditional disease model in medicine to preventive care

As part of our partnership, your progress on the Cenegenics program will be monitored and evaluated on an ongoing basis, consistently measuring your current state versus your goals.

• Easy access to your clinical team including your physician and exercise and nutrition consultant

• Modifications of your Cenegenics program by your Cenegenics physician based on blood work results and clinical progress

• Ongoing modifications of your exercise plan based on your own fitness level, motivation and lifestyle

• Close monitoring and fine-tuning of your nutrition program to ensure you are getting good results

• Medical grade vitamins and supplements

Additional Cutting-Edge Testing

In addition to your customized program, you may consider additional testing based on your current needs, such as: 

  • Heart Disease & Stroke Prevention Program
  • Genomic (DNA) Testing
  • Telomere Measurement
  • Micronutrient Testing
  • Food Allergy Testing

Reaching Your Health Potential with Cenegenics

Couple with increased zest for life because of Cenegenics program, Couple improved well-being after Cenegenics Elite Health Evaluation, Couple prepares healthy meal to support life-changing program

Cenegenics provides you with a complete life changing program—one built on low-glycemic and anti-inflammatory nutrition, exercise, nutraceutical supplementation and hormone optimization. No single element stands alone. Its effect keeps your body in perfect harmony and supports your prime objective—realizing your health goals and enjoying a life filled with vigor and a heightened sense of well-being.

Cenegenics has helped over 35,000 patients dramatically change their vitality and optimize their health. Visit our Cenegenics Reviews Page to hear about Cenegenics Patients' experiences on the Cenegenics Elite Health Programs.

Cenegenics in the Media

Cenegenics continues to capture media attention around the world, recognized as a leading authority on age management medicine.

Cenegenics’ media exposure includes CNBC, Bloomberg, The Wall Street Journal, GQ, Men’s Health, Forbes, NY Times and more.

What is Cenegenics – In Conclusion

Cenegenics is the clinical leader in age management medicine, providing a preventive approach by offering state-of-the-art comprehensive programs that are tailored to each patient’s health goals.

Next Steps to Schedule Your Health Evaluation with Cenegenics

FREE Consultation

Our world class physicians create a personalized plan to help you feel 10+ years younger. You'll be more energetic, lose weight, sleep better, have more libido, and think more clearly. Click below to schedule a free consultation with one of our physicians. It's quick + easy. 

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.

Overexposure to sunlight can prematurely age your skin and cause uneven pigmentation, Cenegenics skin care products are designed to rebuild aging and sun-damaged skin

Summer is Around the Corner: Start Protecting Your Skin from Signs of Aging

Elite-April-FacialNow is the time to get outside and enjoy the sunshine and fresh air! However, the sun can be a harsh benefactress. While she can lift your spirits and warm you, exposure to sunlight can prematurely age your skin and cause uneven pigmentation. To truly enjoy the sun and properly care for your skin, consider the Cenegenics Skin Care Line, specifically designed to help reduce the marks of aging caused by excessive sun exposure.

Step #1: Clean

While many of us left acne behind in high school, others find it cropping back up as we pass through menopause or andropause. The Cenegenics Purifying Cleanser is a gentle yet thorough cleansing product, ideal for removing make-up, clearing away any oil residue and preparing your skin for toning and restoration.

This cleanser gently clears away natural and artificial products that may be blocking your pores and allows your skin to breath naturally. While many cleansing products can strip the skin, leaving it feeling dry and tight, the Cenegenics product line is, first and foremost, kind to your skin.

Radiance-Package_WR_1024x1024Step #2: Tone

The refining toner offered by Cenegenics will balance your skin and prepare it for deep moisture with stem cell activators designed to balance your complexion. Toning is a critical step that makes the rest of your skin care regimen more effective.

The ingredients in Cenegenics toner offer tremendous antimicrobial characteristics and anti-inflammatory properties. If inflammation or acne trouble your aging skin, this toner can help.

Step #3: Restore

Many of the best features of Cenegenics skin products is what they don’t put on your face. No mineral oil, animal derivatives or synthetic fragrances means there’s nothing in this quality restorative serum that will clog your pores or damage your skin. In fact, this serum can help activate the immune function inherent in your skin.

Cenegenics Restorative Serum guards and cares for the skin thanks to several specific ingredients. From rose canina seed extract, used to treat wounds and scars, to caviar extract for collagen enhancing, this serum was designed and blended with aging skin in mind.

Step #4: Activate

The Cenegenics skin care regimen does more than clean and refresh your skin; these products can actually help you rebuild lost elasticity and firmness. The epidermal activation treatment is a spray-on product that places peptides directly on your skin to encourage collagen production and reduce wrinkles.

This product is built to work with your biology and awaken dormant stem cells in your own epidermis. As your skin is an integral part of your immune system as well as the largest organ of your body, Cenegenics skin care products contribute to your total health.

Step #5: Moisturize

It’s important to note that many products in the Cenegenics Skin Care Line offer EGF (epidermal growth factors) in their formulas to give you not only clean, fresh skin but also restorative technology that can strengthen the proteins in your dermal tissues, reducing the tendency of aging skin to fall into wrinkles. The rejuvenating moisturizer is the final and critical application of these powerful proteins.

The lipids found in Cenegenics Moisturizer come from safflower and olives, giving you a light feel on the skin with powerful moisturizing capabilities. This product will not only moisturize your skin, it will help it to firm and reduce the look of papery, thin skin.


Many skincare products offer glamorous packaging and air-brushed models, but few provide users the science and the technology necessary to truly rebuild aging and sun=damaged skin. Cenegenics combines the force of nature with the precision of science to give users an exact formula for skin that looks and feels younger.

Cenegenics can help effectively manage the progression of aging by helping individuals maintain optimal health and vitality

Cenegenics Elite Health Program: Why You Should Consider Age Management Your Next Investment

Your body holds deep wisdom. Trust in it. Learn from it. Nourish it. Watch your life transform and be healthy

Bella Bleue

Age management is the most important investment a person makes in a lifetime. Aging seems like a disease to many people, a time when systems inevitably fail and chronic conditions interfere with quality of life.

At times, growing older seems an uncontrollable ride downhill with no recourse but to hang on. Can the brakes be applied? At Cenegenics, they know that aging is a natural process that can be effectively managed through their advanced Cenegenics Elite Health Program, designed to help individuals maintain optimal health and vitality.

Cenegenics Is Not Traditional Medicine

Mature man running on beach

Aging is not a disease, any more than adolescence or childhood is a disease. Instead these are life stages, each with its precautions and advantages. As health care for infants has all but eliminated conditions that stole childhood, so research today has discovered successful ways to alleviate the chronic conditions that deprive middle aged men and women of vitality and productivity.

Cenegenics does not subscribe to traditional medicine’s fix-it-when-it’s broken and diagnose-and-treat philosophies. Cenegenics' physicians believe and practice proactive, preventive medical care, enhancing health rather than waiting for age-related diseases such as:

Here are three important reasons to investigate today's opportunities for revising the aging process.

Diminishing Hormones

Much discussion has been given to hormone replacement therapy, not all of it accurate. Most have been led to believe that hormonal supplementation may be detrimental to health, so they are adamant to 'go natural' and hope for the best. Unfortunately, the natural process of losing hormones is catastrophic to lifestyles for those in their 40’s and 50’s.

Low testosterone is related to more than sexual performance. Vitality, strong bones, cardiac health, mental acuity and emotional stability are all related to proper hormonal balance. Supporting optimal hormonal activity is crucial to quality of life. Cenegenics utilizes bioidentical hormones and advanced nutraceuticals as part of their distinctive approach to age management.

Physical Strength

Young people usually have plenty of muscle mass and strength without much effort. By the time a person reaches the fifth of sixth decade of life, that muscle mass and its advantages have diminished greatly, particularly if steps were not taken to retain it.

Weight-lifting prolongs life, lowers blood pressure and prohibits the weight gain and negative body reconfiguration common to aging. Chances of sudden death for any reason is 46 percent lower in those who follow a consistent program of resistance training. 

Cenegenics will spend quality time with you discussing your current approach to exercise to help determine your cardiovascular endurance, body composition and bone density so you can best achieve your personal goals.


It would seem that optimal nutrition would be a given for physical and mental achievement. However, the ability to absorb nutrients from the table diminishes with aging. This is where Cenegenics' extensive nutrition consultation and information regarding nutritional supplementation comes in. Cenegenics' physicians understand the importance of a healthy and balanced diet and how each person’s body requires a different approach; nutritional supplementation is no different. 

Discussing existing dietary habits and how to make the right food choices will allow a clear path towards optimum physical health. Cenegenics' physicians priority is not simply providing you with generic information about health. It’s much more: Cenegenics' goal is to help you gain the confidence you need to make the right choices for your specific needs.

Cenegenics Elite Health Program understands the science behind Age Management Medicine. Investment in your health trumps all the other investments a person may make. Visit Cenegenics.com today and Request Your FREE Consultation.

Next Steps to Learning More About Cenegenics Elite Health

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About the Contributor

Rudy Inaba 
Global Director of Nutrition & Exercise

Rudy Inaba is Cenegenics’ Global Director of Nutrition & Exercise. He is a recognized fitness and sports nutrition consultant with nearly 15 years of experience in clinical exercise physiology and lifestyle management. After pursuing his Master of Science in Clinical Exercise Physiology at the University of Nevada Las Vegas, Rudy joined Cenegenics where he leads 20 clinical locations nationwide in their advancements in kinesiology, nutritional biochemistry, and their analyses of industry research & market trending.

Key Resources

This guide was produced with contributions from the following key resources: 

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 1: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

The Cenegenics Education and Research Foundation  

The Textbook of Age Management Medicine Volume 2: Mastering Healthy Aging Nutrition, Exercise and Hormone Replacement Therapy

Click to purchase

Textbook Authors:

Jeffrey Park Leake, M.D., CPT

Dr. Jeffrey Park Leake is a Partner and Director of Education at Cenegenics Elite Health specializing in age management and wellness. Having trained hundreds of physicians worldwide, Dr. Leake is also the Director of Education for the Clinical Strategies for Healthy Aging course at AMM Educational Foundation.

Todd David Greenberg, M.D., CSCS

Dr. Todd Greenberg is a practicing physician with a broad range of expertise, including wellness, exercise, sports injuries, and MRI of sports injuries. He is a Radiology Clinical Associate Professor at the University of Washington.

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